| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | TS; TXS; CYP5; THAS; TXAS; CYP5A1; GHOSAL; BDPLT14 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human TBXAS1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TBXAS1抗体的3篇参考文献示例(注：以下内容为模拟示例，实际文献需通过学术数据库检索确认)：
1. **文献名称**：*"Thromboxane synthase expression in human colorectal carcinoma: association with tumor progression"*
**作者**：Smith A, et al.
**摘要**：本研究通过免疫组化技术使用TBXAS1抗体，分析了结直肠癌组织中血栓烷合酶的表达水平，发现其高表达与肿瘤转移和不良预后显著相关。
2. **文献名称**：*"Role of TBXAS1 in atherosclerotic plaque instability: immunohistochemical and Western blot analysis"*
**作者**：Zhang L, et al.
**摘要**：利用TBXAS1抗体对动脉粥样硬化斑块组织进行检测，发现斑块中TBXAS1表达升高与炎症细胞浸润及斑块不稳定性密切相关。
3. **文献名称**：*"Genetic ablation of Tbxas1 alters platelet function and protects against thrombosis in mice"*
**作者**：Johnson R, et al.
**摘要**：通过TBXAS1抗体验证基因敲除小鼠模型中该蛋白的缺失，并发现缺失后血小板血栓烷A2合成减少，显著降低血栓形成风险。
如需具体文献，建议在PubMed或Google Scholar中检索关键词“TBXAS1 antibody”或“thromboxane synthase antibody”获取最新研究。
The TBXAS1 antibody targets thromboxane A synthase 1 (TBXAS1), an enzyme encoded by the TBXAS1 gene, which plays a critical role in the arachidonic acid metabolic pathway. TBXAS1 catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent mediator of platelet aggregation, vasoconstriction, and smooth muscle proliferation. Dysregulation of TBXAS1 activity or expression has been implicated in cardiovascular diseases, thrombotic disorders, and certain cancers, making it a focus of both basic and clinical research.
Antibodies against TBXAS1 are essential tools for studying its expression, localization, and function in various tissues and disease models. They are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and ELISA to quantify protein levels or assess tissue-specific distribution. Researchers also employ TBXAS1 antibodies to investigate its role in pathological conditions, including atherosclerosis, hypertension, and tumor angiogenesis.
Commercial TBXAS1 antibodies are typically raised in hosts like rabbits or mice, with formats ranging from monoclonal to polyclonal. Specificity is validated using knockout cell lines or siRNA-mediated knockdowns to ensure minimal cross-reactivity. Recent studies highlight TBXAS1's potential as a therapeutic target, driving demand for high-quality antibodies in drug development and biomarker discovery. However, variability in antibody performance across applications necessitates careful validation for experimental reproducibility.
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