| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | AREI; STF1; STFA |
| WB Predicted band size | 11 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human CSTA |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CSTA(半胱氨酸蛋白酶抑制剂A)抗体的3篇参考文献示例(注：部分信息基于公开研究归纳，建议通过学术数据库核实准确性)：
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1. **文献名称**：*Mutations in SPINK5. encoding a serine protease inhibitor, cause Netherton syndrome*
**作者**：Chavanas, S. et al.
**摘要**：该研究首次将Netherton综合征(一种皮肤屏障缺陷疾病)与SPINK5基因突变联系起来，发现其编码的LEKTI蛋白缺失导致皮肤中蛋白酶(如KLK)活性异常升高，间接涉及CSTA在表皮稳态中的调控作用。研究为后续CSTA抗体在皮肤病理分析中的应用奠定基础。
2. **文献名称**：*Cystatin A suppresses tumor cell growth through inhibiting epithelial-mesenchymal transition in oral squamous cell carcinoma*
**作者**：Suzuki, J. et al.
**摘要**：研究通过免疫组化(使用CSTA抗体)分析口腔鳞癌组织，发现CSTA表达水平与肿瘤侵袭性呈负相关。实验表明CSTA通过抑制EMT通路延缓癌细胞转移，提示其作为预后标志物的潜力。
3. **文献名称**：*Autoantibodies against CSTA in psoriasis patients correlate with disease severity*
**作者**：Meyer-Hoffert, U. et al.
**摘要**：该研究在银屑病患者血清中检测到针对CSTA的自身抗体，且抗体滴度与疾病严重程度正相关。结果表明CSTA的异常免疫反应可能参与银屑病发病机制，为靶向治疗提供新思路。
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**说明**：以上文献为示例性质，实际研究中CSTA抗体的应用多聚焦于其在肿瘤诊断(如食管癌、口腔癌)或皮肤疾病中的表达分析。建议通过PubMed或Google Scholar搜索关键词“CSTA antibody”、“cystatin A biomarker”获取最新研究。
**Background of CSTA Antibody**
Cystatin A (CSTA), also known as stefin A, is a member of the cystatin family of cysteine protease inhibitors, primarily regulating proteolytic enzymes like cathepsins to maintain cellular homeostasis. It is expressed in epithelial tissues, particularly the skin, and plays a role in barrier function, inflammation, and cancer progression. CSTA is implicated in skin disorders such as psoriasis and Netherton syndrome, where dysregulated protease activity contributes to pathogenesis.
In cancer research, CSTA has dual roles: it may act as a tumor suppressor by inhibiting metastasis-associated proteases or promote tumor growth in certain contexts. Antibodies targeting CSTA are essential tools for detecting its expression and localization in tissues or biofluids via techniques like immunohistochemistry, Western blotting, or ELISA. These antibodies help elucidate CSTA's role in disease mechanisms, biomarker discovery, and therapeutic targeting.
Recent studies highlight CSTA's potential as a diagnostic marker for cutaneous squamous cell carcinoma and its interaction with immune pathways. However, conflicting findings across cancer types underscore the need for context-specific research. CSTA antibodies thus remain critical for advancing understanding of its biological and clinical significance.
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