| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human CST6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CST6抗体的示例参考文献(内容为模拟概括，建议通过学术数据库核实最新研究)：
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1. **文献名称**：*Cystatin 6 (CST6) as a biomarker in serous ovarian carcinoma: Immunohistochemical analysis*
**作者**：Zhang Y, et al. (2017)
**摘要**：研究通过CST6抗体进行免疫组化分析，发现CST6在卵巢癌组织中高表达，且与患者预后不良相关，提示其可能作为潜在治疗靶点。
2. **文献名称**：*Development of a monoclonal antibody against CST6 and its application in breast cancer progression*
**作者**：Wang L, et al. (2015)
**摘要**：开发了针对CST6的单克隆抗体，实验表明抑制CST6可减少乳腺癌细胞侵袭，抗体为研究CST6在肿瘤转移中的作用提供了工具。
3. **文献名称**：*Epigenetic silencing of CST6 in oral squamous cell carcinoma: Validation by antibody-based assays*
**作者**：Chen H, et al. (2020)
**摘要**：利用CST6抗体验证口腔鳞癌中CST6的表观遗传沉默，发现其启动子甲基化导致表达下调，与肿瘤分化程度相关。
4. **文献名称**：*CST6 as a prognostic marker in head and neck cancer: Correlation studies using antibody-mediated detection*
**作者**：Liu X, et al. (2018)
**摘要**：通过抗体检测头颈癌患者组织中CST6水平，发现低表达与淋巴结转移和生存率下降显著相关，支持其作为预后标志物。
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**备注**：以上内容为示例，实际文献需通过PubMed、Google Scholar或Web of Science等平台检索关键词(如“CST6 antibody”“Cystatin 6 cancer”)获取最新研究。
The cystatin superfamily comprises cysteine protease inhibitors involved in regulating proteolytic activity. Cystatin 6 (CST6), a member of the type 1 cystatin family, is encoded by the *CST6* gene and functions as an extracellular inhibitor of cathepsins, enzymes linked to tissue remodeling, inflammation, and cancer progression. Unlike other cystatins, CST6 contains a unique signal peptide for secretion and a conserved cystatin domain, enabling extracellular protease regulation.
Research highlights CST6's dual role in cancer biology. It exhibits tumor-suppressive properties in some contexts by inhibiting cathepsin-mediated invasion and metastasis, notably in breast and ovarian cancers. However, its overexpression in other malignancies, such as oral squamous cell carcinoma, correlates with poor prognosis, suggesting context-dependent functions. CST6 is also implicated in skin barrier formation and immunological processes.
CST6 antibodies are critical tools for detecting CST6 expression in tissues or biofluids via immunohistochemistry, Western blotting, or ELISA. These antibodies aid in studying CST6's role in disease mechanisms, validating its potential as a diagnostic or prognostic biomarker, and exploring therapeutic strategies targeting protease pathways. Commercial CST6 antibodies are typically validated for specificity against recombinant or endogenous proteins, though variability in experimental conditions requires careful optimization. Ongoing research seeks to clarify CST6's regulatory networks and clinical relevance across pathologies.
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