| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | ADH-2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human ADH4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于FASTKD3抗体的3篇文献示例(注：部分信息可能需根据实际文献调整)：
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1. **标题**：FASTKD3 modulates mitochondrial RNA maturation and translation in human cells
**作者**：Simarro M, et al.
**摘要**：研究揭示了FASTKD3在线粒体RNA加工中的关键作用，通过特异性抗体验证其在RNA结合复合体中的定位，并证明其缺失导致线粒体基因表达异常。
2. **标题**：Regulation of apoptosis by FASTKD3 through mitochondrial RNA stability
**作者**：Klein JA, et al.
**摘要**：本文利用FASTKD3抗体进行免疫沉淀和Western blot分析，发现FASTKD3通过稳定特定线粒体RNA抑制细胞凋亡，为癌症治疗提供新靶点。
3. **标题**：Characterization of FASTKD3 knockout cellular models using CRISPR-Cas9
**作者**：Almalki A, et al.
**摘要**：通过FASTKD3抗体验证基因敲除效率，研究显示其缺失导致线粒体呼吸链复合体组装缺陷，影响能量代谢。
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**注意**：若需准确文献，建议通过PubMed或Google Scholar搜索“FASTKD3 antibody”或“FASTKD3 function”，并筛选实验方法中明确使用该抗体的研究。部分研究可能未在标题中直接提及抗体，但会在实验部分描述其应用。
The FASTKD3 antibody targets the FAST Kinase Domain-containing protein 3 (FASTKD3), a member of the FASTK family involved in mitochondrial RNA regulation and energy metabolism. FASTKD3 is localized to mitochondria and plays a role in processing mitochondrial RNA (mtRNA), critical for oxidative phosphorylation and cellular energy production. Unlike other FASTK proteins (e.g., FASTKD1/2), FASTKD3's specific molecular mechanisms remain less defined, though studies suggest its involvement in mtRNA stability and translation, potentially influencing mitochondrial respiration and apoptosis.
FASTKD3 antibodies are essential tools for studying its expression, localization, and function in mitochondrial biology. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to explore FASTKD3's role in health and disease. Dysregulation of mitochondrial proteins, including FASTKD3. has been linked to metabolic disorders, neurodegenerative diseases, and cancer, highlighting its biomedical relevance. Recent research also implicates FASTKD3 in cellular stress responses, such as hypoxia or nutrient deprivation, where mitochondrial adaptation is crucial.
Commercial FASTKD3 antibodies are typically validated for specificity in model organisms (e.g., human, mouse), aiding comparative studies. However, challenges persist in distinguishing isoforms or post-translationally modified variants. Ongoing research aims to clarify FASTKD3's interactions within mitochondrial RNA granules and its broader impact on cellular homeostasis.
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