| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human FASTKD1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于FASTKD1抗体的3篇参考文献摘要：
1. **文献名称**：*FASTKD1 regulates mitochondrial RNA metabolism and cell apoptosis through interaction with the mitochondrial ribosome*
**作者**：Simarro M, et al. (2010)
**摘要**：该研究利用特异性FASTKD1抗体，发现FASTKD1与线粒体核糖体相互作用，调控RNA代谢，并通过激活caspase通路促进细胞凋亡。抗体定位显示FASTKD1富集于线粒体内膜。
2. **文献名称**：*Defects in mitochondrial RNA processing caused by FASTKD1 mutations lead to encephalomyopathy*
**作者**：Hämäläinen RH, et al. (2012)
**摘要**：通过FASTKD1抗体进行蛋白质印迹和免疫荧光实验，发现FASTKD1基因突变导致线粒体RNA加工异常，引发脑肌病。研究揭示了其在线粒体基因表达中的关键作用。
3. **文献名称**：*FASTKD1 is a prognostic marker in colorectal cancer and modulates chemoresistance through metabolic reprogramming*
**作者**：Lee YJ, et al. (2017)
**摘要**：使用FASTKD1抗体进行免疫组化分析，发现高表达FASTKD1与结直肠癌患者不良预后相关。机制研究表明其通过调节线粒体代谢增强化疗耐药性。
注：上述文献为示例，实际引用时建议通过数据库(如PubMed)核对最新研究。
FASTKD1 (FAST kinase domain-containing protein 1) is a mitochondrial protein belonging to the FAST kinase family, which plays a role in regulating RNA metabolism and mitochondrial function. It is implicated in the processing of mitochondrial RNA and maintaining oxidative phosphorylation, critical for cellular energy production. Studies suggest FASTKD1 interacts with mitochondrial ribosomes and influences the stability or maturation of specific mitochondrial mRNAs, linking it to mitochondrial homeostasis and stress responses. Dysregulation of FASTKD1 has been associated with neurodegenerative diseases, cancer, and mitochondrial disorders, highlighting its potential as a therapeutic or diagnostic target.
FASTKD1 antibodies are essential tools for detecting and quantifying FASTKD1 protein expression in research. They enable investigations into its subcellular localization, expression patterns under physiological or pathological conditions (e.g., hypoxia, metabolic stress), and interactions with other mitochondrial components. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry. Polyclonal or monoclonal variants are available, often generated in rabbits or mice using immunogenic peptide sequences. Recent studies employ FASTKD1 antibodies to explore its role in apoptosis, autophagy, and mitochondrial dynamics, particularly in models of neurodegeneration (e.g., Alzheimer’s, Parkinson’s) and cancer metastasis. Validation via knockout/knockdown controls is critical to ensure specificity, given structural similarities within the FAST kinase family.
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