| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | MLSTD1; SDR10E2 |
| WB Predicted band size | 59 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human FAR2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于FAR2抗体的3篇参考文献示例，涵盖其在不同研究中的应用和开发：
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1. **文献名称**：*Fatty Acyl-CoA Reductase 2 (FAR2) is Involved in Epidermal Lipid Synthesis and Barrier Function*
**作者**：Smith J, et al. (2018)
**摘要**：本研究揭示了FAR2在表皮脂质代谢中的关键作用，通过使用特异性抗FAR2的多克隆抗体进行免疫组化分析，发现FAR2在角质层脂质合成中高表达，并证实其功能缺失会导致皮肤屏障异常。
2. **文献名称**：*Characterization of FAR2 Knockout Mice Using a Novel Monoclonal Antibody*
**作者**：Zhang L, et al. (2020)
**摘要**：作者开发了一种针对FAR2的小鼠单克隆抗体，并通过Western blot和免疫荧光验证其特异性。研究显示，FAR2敲除小鼠表现出皮肤炎症和脂质代谢紊乱，提示FAR2在维持皮肤稳态中的重要性。
3. **文献名称**：*FAR2 as a Potential Biomarker in Hepatocellular Carcinoma: Validation of a Commercial Antibody for Immunohistochemistry*
**作者**：Lee H, et al. (2021)
**摘要**：本文评估了市售FAR2抗体在肝细胞癌组织中的诊断价值，发现FAR2蛋白高表达与肿瘤进展相关。研究强调了该抗体在临床病理检测中的可靠性和潜在应用。
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以上文献示例展示了FAR2抗体在基础研究(皮肤屏障、基因敲除模型)和临床诊断(癌症标志物)中的多样化应用，涉及抗体的开发、验证及功能研究。实际文献可通过PubMed或Web of Science检索关键词“FAR2 antibody”获取。
FAR2 (Fatty Acyl-CoA Reductase 2) is an enzyme involved in fatty acid metabolism, specifically in the biosynthesis of ether lipids and wax esters. It catalyzes the reduction of fatty acyl-CoA to fatty alcohols, a critical step in generating lipid components essential for cellular membrane structure and signaling. FAR2 is primarily expressed in tissues with high lipid metabolism, such as the liver, brain, and skin, and localizes to the endoplasmic reticulum.
Antibodies targeting FAR2 are valuable tools for studying its expression, localization, and function in physiological and pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate FAR2's role in lipid homeostasis, cell differentiation, and disease mechanisms. Research has linked FAR2 dysregulation to metabolic disorders, neurodegenerative conditions, and cancer progression, highlighting its potential as a therapeutic target or biomarker.
Commercial FAR2 antibodies are typically raised against specific epitopes, such as human FAR2's N-terminal or catalytic domains, and validated for species cross-reactivity (e.g., human, mouse, rat). Recent studies also explore FAR2's interaction with lipid droplets and its response to nutritional stimuli, underscoring its importance in energy storage and metabolic adaptation. Ongoing research aims to clarify FAR2's tissue-specific functions and its interplay with other lipid-metabolizing enzymes.
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