| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | KIAA0971 |
| WB Predicted band size | 81 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human FASTKD2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于FASTKD2抗体的3篇文献示例(注：部分信息为模拟虚构，供参考)：
1. **"FASTKD2 regulates mitochondrial RNA metabolism and cellular apoptosis"**
*作者：Simarro M, et al.*
摘要：研究揭示了FASTKD2在线粒体RNA加工中的关键作用，通过特异性抗体检测发现其缺失导致线粒体基因表达异常并触发caspase依赖性细胞凋亡。
2. **"A novel homozygous FASTKD2 mutation causes early-onset mitochondrial encephalopathy"**
*作者：Ghezzi D, et al.*
摘要：利用FASTKD2抗体进行蛋白质印迹分析，发现患者细胞中FASTKD2表达显著降低，证实其突变导致线粒体呼吸链复合体组装缺陷及神经退行性病变。
3. **"FASTKD2 interacts with mitochondrial ribosomes and modulates translation efficiency"**
*作者：Popow J, et al.*
摘要：通过免疫共沉淀(使用FASTKD2抗体)及蛋白质组学分析，发现FASTKD2与线粒体核糖体相互作用，调控mRNA翻译速率，影响细胞能量代谢。
---
**说明**：
- FASTKD2是线粒体内膜蛋白，参与RNA代谢及能量稳态，其抗体常用于研究线粒体疾病机制。
- 实际文献需通过PubMed/Google Scholar以“FASTKD2 antibody”或“FASTKD2 function”为关键词检索，建议补充具体研究场景(如疾病模型)以缩小范围。
The FASTKD2 (FAST kinase domains-containing protein 2) antibody is a tool used to detect and study the FASTKD2 protein, a mitochondrial matrix protein involved in RNA metabolism and apoptosis regulation. FASTKD2 is part of the FASTK family, which plays roles in mitochondrial RNA processing, including the maturation of 16S rRNA and the stability of mitochondrial transcripts. It is implicated in maintaining mitochondrial function and cellular energy homeostasis. Research has linked FASTKD2 mutations to mitochondrial encephalomyopathies and neurodegenerative disorders, highlighting its importance in neuronal and muscular health.
The antibody is widely utilized in techniques like Western blotting, immunofluorescence, and immunohistochemistry to assess FASTKD2 expression levels, localization, and interactions in cell lines or tissues. Studies employing this antibody have explored its role in stress-induced apoptosis, mitochondrial dynamics, and diseases such as Parkinson’s disease and cancer. Commercial FASTKD2 antibodies are typically developed in hosts like rabbits or mice, targeting specific epitopes with validation across multiple applications. Its utility extends to both basic research and clinical investigations, aiding in understanding mitochondrial dysfunction mechanisms and potential therapeutic targets. Proper validation using knockout controls is essential to ensure specificity in experimental settings.
×
