| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | dJ1187M17.5 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human FASTKD5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于FASTKD5抗体的3篇模拟参考文献(基于学术文献常见结构模拟，非真实存在)：
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1. **文献名称**：*FASTKD5 modulates mitochondrial RNA stability and apoptosis in human cells*
**作者**：Simarro M., et al.
**摘要**：本研究揭示了FASTKD5作为线粒体RNA结合蛋白的功能，通过敲低实验证明其参与调控线粒体编码基因的RNA稳定性。研究使用特异性FASTKD5抗体进行免疫印迹和免疫荧光，证实其在HeLa细胞线粒体中的定位，并发现其缺失导致细胞凋亡增加。
2. **文献名称**：*Loss of FASTKD5 perturbs mitochondrial architecture and respiratory chain complex assembly*
**作者**：Lee J., Ryu S.
**摘要**：通过CRISPR/Cas9技术构建FASTKD5敲除细胞系，结合FASTKD5抗体进行蛋白质互作组学分析，发现FASTKD5与线粒体核糖体蛋白相互作用。研究显示FASTKD5缺失导致呼吸链复合体I和IV组装异常，提示其在氧化磷酸化中的关键作用。
3. **文献名称**：*FASTKD5 antibody-based screening identifies its role in neurodegenerative disease models*
**作者**：Kumar A., et al.
**摘要**：利用FASTKD5单克隆抗体对阿尔茨海默病模型小鼠脑组织进行蛋白质表达分析，发现FASTKD5水平显著降低，且与线粒体DNA拷贝数减少相关。体外实验表明过表达FASTKD5可缓解Aβ诱导的神经元凋亡。
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**注**：以上文献为示例性质，实际研究中建议通过PubMed、Google Scholar等平台以“FASTKD5 antibody”或“FASTKD5 function”为关键词检索最新文献。若需具体论文，可进一步提供领域方向(如神经生物学、癌症等)以缩小范围。
The FASTKD5 (FAS-activated serine/threonine kinase domain-containing protein 5) antibody is a tool used to study the function and expression of the FASTKD5 protein, a member of the FASTK family implicated in mitochondrial RNA metabolism and cellular stress responses. FASTKD5 localizes to mitochondria and is associated with regulating the stability and processing of mitochondrial RNA (mtRNA), particularly transcripts encoding components of the electron transport chain (ETC). This protein plays a critical role in maintaining mitochondrial function, energy production, and cellular viability under stress conditions. Dysregulation of FASTKD5 has been linked to mitochondrial disorders, neurodegenerative diseases, and cancer, highlighting its importance in cellular homeostasis.
The FASTKD5 antibody enables researchers to detect and quantify FASTKD5 expression in tissues or cultured cells via techniques like Western blotting, immunofluorescence, or immunohistochemistry. It is also utilized to investigate FASTKD5's interaction partners, subcellular localization, and role in apoptotic signaling or metabolic adaptation. Recent studies suggest FASTKD5 may act as a stress-responsive modulator of mtRNA processing, influencing ETC complex assembly and oxidative phosphorylation. Its involvement in pathways like mTOR or AMPK signaling further underscores its potential as a therapeutic target. The antibody thus serves as a vital reagent for exploring mitochondrial biology and disease mechanisms tied to mitochondrial dysfunction.
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