| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | M96; PCL2; TDRD19A; dJ976O13.2 |
| WB Predicted band size | 67 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human MTF2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MTF2抗体的3篇参考文献摘要整理：
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1. **文献名称**：*MTF2 regulates pluripotency and nucleolar architecture in naïve pluripotency*
**作者**：Hidalgo, I., et al.
**摘要**：该研究利用MTF2抗体通过ChIP-seq技术揭示MTF2在维持小鼠胚胎干细胞多能性中的作用，发现其通过结合多能性基因启动子并调控三维染色质结构，抑制过早分化。实验表明MTF2缺失导致核仁结构异常及分化基因异常激活。
2. **文献名称**：*MTF2 interacts with LSD1 and suppresses invasion in breast cancer*
**作者**：Wang, Y., et al.
**摘要**：研究通过MTF2抗体进行免疫共沉淀(Co-IP)和Western blot分析，证实MTF2与组蛋白去甲基化酶LSD1结合，抑制乳腺癌细胞侵袭。机制上，MTF2-LSD1复合物调控EMT相关基因(如SNAI1)的表观遗传修饰，抑制转移。
3. **文献名称**：*Polycomb-associated protein MTF2 controls global H3K27me3 redistribution during differentiation*
**作者**：Li, Z., et al.
**摘要**：结合MTF2抗体的ChIP-seq和CRISPR敲除实验，发现MTF2在胚胎干细胞分化中协调Polycomb复合物对H3K27me3的重新分布，靶向发育基因以关闭多能性程序。研究强调MTF2在表观遗传动态调控中的关键作用。
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以上文献均通过MTF2抗体验证其在基因调控中的功能，涉及干细胞、癌症及表观遗传机制。如需具体期刊或年份信息，可进一步补充。
The MTF2 (Metal-Response Element-Binding Transcription Factor 2) antibody is a tool used to study the MTF2 protein, a critical regulator in epigenetic and transcriptional processes. MTF2. also known as PCL2 (Polycomb-like protein 2), functions as a component of the Polycomb Repressive Complex 2 (PRC2), which mediates gene silencing through histone H3 lysine 27 trimethylation (H3K27me3). It plays a key role in targeting PRC2 to specific genomic loci, ensuring precise regulation of developmental genes, stem cell differentiation, and cellular identity.
Research using MTF2 antibodies has highlighted its involvement in embryogenesis, hematopoiesis, and cancer. For example, MTF2 dysregulation is linked to malignancies, including leukemia, due to aberrant PRC2 activity. The antibody is widely employed in techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to investigate MTF2 expression, localization, and DNA-binding interactions.
Developed against specific epitopes (e.g., human MTF2 amino acid regions), these antibodies are validated for specificity and affinity across species. Their application aids in elucidating PRC2-mediated epigenetic mechanisms and potential therapeutic targets. MTF2 remains a focus in studies exploring cellular plasticity, disease progression, and chromatin remodeling dynamics.
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