Rabbit Polyclonal PSMC2 Antibody

The PSMC2 (Proteasome 26S Subunit, ATPase 2) antibody is a tool used to study the 26S proteasome, a multi-subunit complex critical for ubiquitin-proteasome system-mediated protein degradation. PSMC2. also known as S4 or MSS1. is a member of the AAA-ATPase family and a key component of the 19S regulatory particle of the 26S proteasome. It plays a vital role in recognizing polyubiquitinated substrates, unfolding them, and translocating them into the proteasome’s catalytic core (20S particle) for proteolysis. Dysregulation of PSMC2 is linked to cancers, neurodegenerative disorders, and immune diseases due to its role in maintaining protein homeostasis. The PSMC2 antibody is widely used in Western blotting, immunoprecipitation, and immunofluorescence to investigate proteasome assembly, function, and expression across tissues. It helps researchers explore cellular stress responses, protein quality control mechanisms, and the impact of proteasome inhibitors in therapeutic contexts. Commercial PSMC2 antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes (e.g., human PSMC2 amino acids 100-200). Validation includes reactivity in human, mouse, and rat samples. Its applications span cancer biology, neurobiology, and studies of aging, offering insights into diseases associated with impaired protein degradation pathways.