| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | MTP18; HSPC242 |
| WB Predicted band size | 18 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human MTFP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MTFP1抗体的3篇参考文献及其摘要内容概要：
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1. **文献名称**：*MTP18 is required for mitochondrial fission in mammalian cells*
**作者**：Tondera, D. et al.
**摘要**：该研究首次揭示了MTFP1(MTP18)作为线粒体分裂的关键调控因子，通过特异性抗体检测其在哺乳动物细胞中的表达，发现其通过调控DRP1的活性维持线粒体形态动态平衡，并参与细胞凋亡过程。
2. **文献名称**：*MTFP1 promotes tumor progression and enhances cisplatin resistance in hepatocellular carcinoma*
**作者**：Li, X. et al.
**摘要**：研究利用MTFP1抗体进行Western blot和免疫组化分析，发现MTFP1在肝癌组织中高表达，并通过激活线粒体分裂途径促进肿瘤增殖及化疗耐药性，提示其作为潜在治疗靶点。
3. **文献名称**：*MTFP1 interacts with DRP1 to regulate mitochondrial dynamics and cellular senescence*
**作者**：Wang, Y. et al.
**摘要**：通过免疫共沉淀(使用MTFP1抗体)和共聚焦显微镜技术，本文证实MTFP1与DRP1直接相互作用，调控线粒体分裂，进而影响细胞衰老过程，为衰老相关疾病提供了分子机制解释。
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**备注**：若需获取更多文献，建议通过PubMed或Google Scholar以“MTFP1 antibody”或“MTP18 antibody”为关键词检索，并关注方法学部分描述抗体应用的原始研究。部分文献可能需要通过机构订阅访问全文。
The MTFP1 (Mitochondrial Fission Process 1) antibody is a tool used to detect and study MTFP1. a protein implicated in regulating mitochondrial dynamics, particularly mitochondrial fission. MTFP1. also known as mitochondrial division regulator 1 (MDR1), interacts with the fission machinery, including dynamin-related protein 1 (DRP1), to facilitate mitochondrial fragmentation. This process is critical for maintaining mitochondrial quality control, apoptosis, and cellular energy homeostasis. Dysregulation of MTFP1 has been linked to neurodegenerative diseases, cancer, and metabolic disorders, making it a target for mechanistic and therapeutic research.
The MTFP1 antibody is typically developed in immunized hosts (e.g., rabbits or mice) and validated for specificity via techniques like Western blotting, immunofluorescence, or immunoprecipitation. It aids in identifying MTFP1 expression patterns across tissues or cell lines, assessing its subcellular localization (primarily mitochondrial), and studying its role in stress-induced fission. Researchers also use this antibody to explore MTFP1’s interaction partners and phosphorylation states under varying physiological or pathological conditions. Its application extends to disease models to evaluate mitochondrial dysfunction mechanisms. Proper validation, including knockout/knockdown controls, ensures reliable detection of the ~15-20 kDa protein. This antibody is essential for advancing understanding of mitochondrial biology and its implications in human health.
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