Rabbit Polyclonal NDUFA2 Antibody

The NDUFA2 antibody is a research tool designed to detect the NDUFA2 protein, a critical subunit of mitochondrial Complex I (NADH:ubiquinone oxidoreductase) in the electron transport chain. NDUFA2. encoded by the nuclear *NDUFA2* gene, is an accessory subunit of Complex I, which plays a central role in oxidative phosphorylation by catalyzing NADH oxidation and electron transfer to ubiquinone. This 10.5 kDa protein is integral to Complex I assembly, stability, and function, though its precise mechanistic role remains under investigation. Dysregulation or mutations in NDUFA2 have been linked to mitochondrial disorders, such as Leigh syndrome, and neurodegenerative conditions, highlighting its importance in cellular energy metabolism. Antibodies targeting NDUFA2 are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study protein expression, localization, and Complex I integrity in disease models. They are particularly valuable in research on mitochondrial dysfunction, aging, and metabolic diseases. Validation of these antibodies typically includes knockdown/knockout controls and cross-reactivity assessments to ensure specificity. Commercial NDUFA2 antibodies are often raised in rabbits or mice using synthetic peptides or recombinant proteins as immunogens. Their application has advanced understanding of Complex I biology and its implications in human pathologies.