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Rabbit Polyclonal NECTIN2 Antibody

  • 中文名: NECTIN2抗体
  • 别    名: HVEB; PRR2; CD112; PVRL2; PVRR2
货号: IPDX08561
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/2000-1/5000 Human,Mouse,Rat

产品详情

AliasesHVEB; PRR2; CD112; PVRL2; PVRR2
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human NECTIN2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于NECTIN2抗体的示例参考文献(注:内容为示例,建议通过学术数据库获取真实文献):

1. **文献名称**: *Nectin-2 as a novel target for antibody-mediated cancer immunotherapy*

**作者**: Smith A, et al.

**摘要**: 研究开发了靶向NECTIN2的单克隆抗体,验证其在体外和体内模型中抑制肿瘤生长的效果,表明其通过增强免疫细胞活性和阻断肿瘤细胞迁移发挥作用。

2. **文献名称**: *Detection of NECTIN2 expression in gastric adenocarcinoma using immunohistochemistry*

**作者**: Zhang L, et al.

**摘要**: 利用特异性抗NECTIN2抗体对胃癌组织进行染色,发现NECTIN2高表达与患者预后不良相关,提示其作为潜在生物标志物的价值。

3. **文献名称**: *Role of Nectin-2 in herpes simplex virus entry and antibody-mediated neutralization*

**作者**: Suzuki K, et al.

**摘要**: 研究证实NECTIN2是HSV-1进入细胞的辅助受体,开发的中和抗体可显著抑制病毒入侵,为抗病毒治疗提供新策略。

4. **文献名称**: *Anti-NECTIN2 antibodies modulate immune synapse formation in T-cell activation*

**作者**: Brown R, et al.

**摘要**: 探索NECTIN2抗体对免疫突触形成的影响,发现其能增强T细胞与抗原呈递细胞的相互作用,提示其在免疫调节治疗中的潜力。

背景信息

The NECTIN2 antibody targets Nectin-2 (also known as PVRL2 or CD112), a cell adhesion molecule belonging to the nectin family. Nectin-2 is a transmembrane protein involved in forming adherens and tight junctions, facilitating cell-cell adhesion in epithelial and endothelial tissues. It also plays roles in immune regulation, viral entry (e.g., as a receptor for herpes simplex virus and pseudorabies virus), and synaptic organization. In cancer biology, NECTIN2 is overexpressed in certain tumors and interacts with immune checkpoint receptors like TIGIT and CD226. modulating anti-tumor immune responses. Antibodies against NECTIN2 are used to study its expression, localization, and function in normal and diseased tissues. Therapeutic NECTIN2-targeting antibodies, such as those blocking viral entry or enhancing immune activation, are under investigation. Research tools include monoclonal and polyclonal antibodies validated for techniques like immunohistochemistry, flow cytometry, and Western blot. Recent studies highlight its potential as a biomarker or therapeutic target in cancers and infectious diseases, driving interest in developing NECTIN2-specific biologics.

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