| WB | 1/200-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | PPR3; PRR3; CD113; PVRL3; PVRR3; CDW113; NECTIN-3 |
| WB Predicted band size | 61 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human NECTIN3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是3篇与NECTIN3抗体相关的文献示例(注：内容为模拟概括，实际文献需通过数据库核实)：
1. **文献名称**：*Nectin-3 modulates the invasive activity of ovarian cancer cells through regulation of metalloproteinases*
**作者**：Samanta D. et al. (2018)
**摘要**：研究利用抗NECTIN3抗体阻断细胞间黏附，发现NECTIN3通过调控MMP2/9表达促进卵巢癌细胞侵袭，提示其作为治疗靶点的潜力。
2. **文献名称**：*Nectin-3 is required for cell-cell adhesion in polarized epithelial cells*
**作者**：Sakisaka T. et al. (2020)
**摘要**：通过免疫组化结合特异性抗体，证实NECTIN3与NECTIN1形成跨膜复合物，维持上皮细胞极性及紧密连接结构，缺失导致屏障功能异常。
3. **文献名称**：*Nectin-3 as a novel biomarker for early-stage colorectal cancer detection*
**作者**：Zhang Y. et al. (2021)
**摘要**：研究开发了高灵敏度抗人NECTIN3单克隆抗体，发现血清NECTIN3水平在结直肠癌早期显著升高，可能成为非侵入性诊断标志物。
4. **文献名称**：*Herpes simplex virus entry mediator Nectin-3 facilitates viral spread in neuronal tissues*
**作者**：Kumar R. et al. (2017)
**摘要**：利用抗NECTIN3抗体阻断实验，揭示HSV-1通过结合神经元表面NECTIN3增强感染效率，为抗病毒治疗提供新策略。
(提示：实际文献请通过PubMed/Google Scholar以“Nectin-3 antibody”等关键词检索获取。)
Nectin-3. a member of the immunoglobulin superfamily, is a cell adhesion molecule encoded by the *NECTIN3* gene. It plays a critical role in forming and maintaining adherens junctions and tight junctions, primarily through homophilic or heterophilic interactions with other Nectins (e.g., Nectin-1) or afadin. Structurally, it consists of three extracellular Ig-like domains, a transmembrane region, and a cytoplasmic tail that mediates intracellular signaling. Nectin-3 is widely expressed in epithelial, endothelial, and neural tissues, contributing to tissue integrity, cell polarization, and synaptic plasticity. Dysregulation of Nectin-3 has been linked to pathologies, including cancer progression, neurological disorders (e.g., Alzheimer’s disease), and viral infections (e.g., herpes simplex virus entry).
Nectin-3 antibodies are tools used to study its expression, localization, and function in both normal and diseased states. In research, these antibodies enable detection via techniques like Western blot, immunohistochemistry, and flow cytometry. Therapeutically, Nectin-3-targeting antibodies are being explored for cancer treatment, as elevated Nectin-3 levels correlate with tumor aggressiveness in ovarian, prostate, and other cancers. Some preclinical studies suggest blocking Nectin-3 interactions may inhibit metastasis or enhance drug delivery. However, clinical applications remain limited, and further validation is needed to assess their efficacy and safety. Overall, Nectin-3 antibodies serve as vital reagents for unraveling biological mechanisms and developing targeted therapies.
×
