Rabbit Polyclonal NUP62 Antibody

The NUP62 antibody targets the nuclear pore complex protein NUP62. a key component of the nuclear pore membrane. NUP62 is part of the FG-repeat nucleoporin family and plays a critical role in nucleocytoplasmic transport by mediating interactions between soluble transport factors and the nuclear pore complex (NPC). It facilitates selective trafficking of macromolecules, including RNA and proteins, across the nuclear envelope. Dysregulation of NUP62 has been linked to various diseases, including cancer, neurodegenerative disorders, and viral infections. For example, altered NUP62 expression is observed in hepatocellular carcinoma and Alzheimer’s disease, where disrupted nucleocytoplasmic transport contributes to pathology. The NUP62 antibody is widely used in research to study NPC structure, cellular stress responses, and disease mechanisms via techniques like immunofluorescence, Western blotting, and immunohistochemistry. Recent studies also explore its role in viral replication, such as hepatitis C virus propagation, highlighting its broader biomedical relevance. Commercial NUP62 antibodies are typically validated for specificity across human, mouse, and rat models, aiding comparative studies in developmental biology and disease models.