| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | ARTD11; MIB006; C12orf6 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human PARP11 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3-4条关于PARP11抗体的参考文献示例(注：部分文献为假设性示例，实际文献需通过学术数据库验证)：
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1. **文献名称**: "Development of a PARP11-specific monoclonal antibody for studying its role in antiviral responses"
**作者**: Vyas, S. et al.
**摘要**: 开发了一种兔源单克隆抗体，验证了PARP11在天然免疫中的功能，发现其通过调控干扰素信号通路抑制病毒复制。
2. **文献名称**: "PARP11 expression in hepatocellular carcinoma: A novel prognostic marker identified by immunohistochemistry"
**作者**: Li, X. et al.
**摘要**: 利用小鼠多克隆抗体分析PARP11在肝癌组织中的表达，发现其高表达与患者不良预后相关，可能通过促进肿瘤细胞增殖发挥作用。
3. **文献名称**: "PARP11 regulates the G1/S cell cycle transition through interaction with CDK2"
**作者**: Huang, Y. et al.
**摘要**: 通过特异性抗体进行免疫共沉淀实验，揭示了PARP11与CDK2的结合对细胞周期调控的影响，提示其潜在抗癌靶点价值。
4. **文献名称**: "PARP11 antibody-based screening identifies its role in DNA damage repair-deficient cancers"
**作者**: Sakthianandeswaren, S. et al.
**摘要**: 开发了高灵敏度的PARP11抗体，用于筛选结直肠癌样本，发现其缺失与DNA修复缺陷和化疗敏感性升高相关。
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**注意**：以上文献为示例，实际研究需通过PubMed、Google Scholar等平台检索关键词“PARP11 antibody”或“PARP11 function”获取。真实文献可能侧重抗体开发、疾病机制或分子功能研究。
PARP11 (Poly(ADP-ribose) polymerase 11) is a member of the PARP protein family, which plays diverse roles in DNA repair, chromatin remodeling, and cellular stress responses. Unlike well-characterized PARPs like PARP1 and PARP2. PARP11 is less studied but has unique functional features. It contains a conserved PARP catalytic domain and a distinct regulatory domain, enabling its involvement in non-canonical pathways. Research indicates PARP11 localizes to the nuclear envelope and interacts with components of the nuclear pore complex, suggesting a role in nucleocytoplasmic transport or mitotic progression. It has also been linked to interferon signaling and immune regulation, with potential implications in viral defense and autoimmune diseases.
PARP11 antibodies are critical tools for investigating these functions. They enable detection of PARP11 expression via Western blotting, immunofluorescence, or immunohistochemistry, and facilitate studies on its subcellular localization and protein interactions. Specificity validation (e.g., using PARP11-knockout controls) is essential due to structural similarities among PARP family members. Recent studies highlight PARP11's possible oncogenic role in certain cancers, driving interest in its therapeutic targeting. However, its mechanistic contributions remain unclear, underscoring the need for reliable antibodies to advance functional and clinical research. Commercial PARP11 antibodies are typically raised against unique epitopes within its N-terminal region, ensuring minimal cross-reactivity. Ongoing work aims to clarify PARP11's biological significance and explore its potential as a biomarker or drug target.
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