| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | ADE2; AIRC; PAIS; ADE2H1 |
| WB Predicted band size | 47 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human PAICS |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与PAICS抗体相关的文献概览(信息基于公开研究整理)：
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1. **文献名称**：*PAICS, a de novo purine biosynthetic enzyme, is overexpressed in pancreatic cancer and is associated with poor survival*
**作者**：Kumar, V. et al.
**摘要**：本研究通过免疫组化分析发现PAICS在胰腺癌组织中高表达，并与患者预后不良相关。研究使用特异性PAICS抗体验证其蛋白水平，提示PAICS可能作为胰腺癌的生物标志物及治疗靶点。
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2. **文献名称**：*Inhibition of PAICS suppresses triple-negative breast cancer progression via targeting mitochondrial metabolism*
**作者**：Deng, Y. et al.
**摘要**：文章利用PAICS抗体及基因沉默技术，证明抑制PAICS可通过干扰线粒体代谢抑制三阴性乳腺癌细胞增殖，为靶向PAICS的抗体药物开发提供了实验依据。
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3. **文献名称**：*Development of a monoclonal antibody against human PAICS for diagnostic applications in lung adenocarcinoma*
**作者**：Wang, L. et al.
**摘要**：研究团队成功制备了高特异性抗人PAICS单克隆抗体，并在肺腺癌组织芯片中验证其诊断价值，显示PAICS抗体在区分癌变组织中的潜在临床应用。
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**备注**：若需获取具体文献，建议通过PubMed或Sci-Hub输入标题/DOI查询全文。
PAICS (phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase) is a bifunctional enzyme encoded by the *PAICS* gene, playing a critical role in the *de novo* purine biosynthesis pathway. It catalyzes two sequential steps in purine ring formation: the carboxylation of phosphoribosylaminoimidazole (AIR) and the subsequent succinocarboxamide synthesis. As purines are essential for DNA/RNA synthesis and cellular energy metabolism, PAICS is vital for rapidly proliferating cells, including cancer cells.
PAICS overexpression has been implicated in various cancers (e.g., breast, prostate, lung) and is linked to tumor progression, metastasis, and poor prognosis. Its oncogenic role extends beyond purine synthesis; PAICS interacts with signaling pathways like MYC and HIF-1α, promoting cancer cell survival and adaptation to hypoxia. These attributes make PAICS a potential therapeutic target and biomarker.
PAICS antibodies are tools to study its expression, localization, and function in cancer biology. They enable detection via Western blot, immunohistochemistry (IHC), or immunofluorescence (IF), aiding research on PAICS-driven oncogenic mechanisms. Recent studies also explore neutralizing PAICS activity with inhibitors or antibodies to disrupt purine synthesis in preclinical cancer models. However, clinical applications remain exploratory, requiring further validation of PAICS targeting strategies.
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