Rabbit Polyclonal PFKL Antibody

The PFKL (phosphofructokinase-liver type) antibody is a crucial tool in studying the role of PFKL, a rate-limiting enzyme in glycolysis that catalyzes the conversion of fructose-6-phosphate to fructose-1.6-bisphosphate. Expressed predominantly in the liver, PFKL regulates glucose metabolism and energy production, with dysregulation linked to metabolic disorders and cancers. Researchers use PFKL antibodies to detect protein expression levels in tissues or cells, aiding investigations into metabolic reprogramming in diseases like hepatocellular carcinoma, where PFKL overexpression often correlates with tumor progression and poor prognosis. These antibodies are employed in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to explore PFKL’s interaction with oncogenic signaling pathways, its role in ATP/AMP balance, and its potential as a therapeutic target. Additionally, PFKL antibodies help elucidate tissue-specific metabolic adaptations in conditions like diabetes or neurodegenerative diseases. Recent studies also highlight PFKL’s non-canonical functions in autophagy and apoptosis, expanding its relevance beyond glycolysis. Validated for specificity and sensitivity, PFKL antibodies are indispensable in both basic research and clinical biomarker discovery, bridging metabolic biology and disease mechanisms.