| WB | 1/200-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | RNF; HCG1; HCGI; C6orf13 |
| WB Predicted band size | 48 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human TRIM31 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于TRIM31抗体的3篇参考文献示例(文献信息为模拟，仅供参考)：
1. **"TRIM31 promotes gastric cancer progression by regulating USP14-mediated AKT/mTOR signaling"**
*作者：Zhang L, et al. (Gastric Cancer, 2021)*
摘要：研究通过TRIM31抗体检测发现其在胃癌组织中高表达，并利用抗体验证其通过调控USP14增强AKT/mTOR信号通路，促进肿瘤侵袭的机制。
2. **"TRIM31 suppresses NLRP3 inflammasome activation by targeting ASC for ubiquitination"**
*作者：Li Y, et al. (Cell Reports, 2020)*
摘要：通过TRIM31抗体免疫共沉淀实验，揭示了TRIM31通过泛素化修饰ASC蛋白抑制NLRP3炎症小体活化，为自身免疫性疾病治疗提供潜在靶点。
3. **"Structural basis of TRIM31-mediated ubiquitination in metabolic regulation"**
*作者：Wang Q, et al. (Nature Communications, 2019)*
摘要：研究结合TRIM31抗体进行免疫印迹和结构分析，解析了TRIM31的E3泛素连接酶活性结构域，阐明其通过泛素化调控肝脏脂代谢的分子机制。
4. **"TRIM31 as a diagnostic biomarker in hepatocellular carcinoma"**
*作者：Chen H, et al. (Hepatology, 2018)*
摘要：通过TRIM31抗体免疫组化分析肝癌组织样本，发现TRIM31高表达与患者预后不良相关，提出其可作为肝癌早期诊断的生物标志物。
(注：以上文献为示例性内容，实际引用需根据真实发表论文调整。)
The TRIM31 antibody is a research tool designed to detect and study the TRIpartite Motif-containing protein 31 (TRIM31), a member of the TRIM family involved in diverse cellular processes, including innate immunity, cancer progression, and antiviral responses. TRIM31 functions as an E3 ubiquitin ligase, mediating protein ubiquitination to regulate signaling pathways such as NF-κB and MAPK, which are critical in inflammation, apoptosis, and stress responses. It also interacts with mitochondrial proteins, influencing oxidative stress and metabolic homeostasis.
Antibodies targeting TRIM31 are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore its expression patterns, subcellular localization, and interactions. Studies highlight TRIM31’s dual roles: it acts as an oncogene in certain cancers (e.g., gastric, colorectal) by promoting proliferation and metastasis, while exhibiting tumor-suppressive effects in others. Additionally, TRIM31 modulates immune signaling by targeting viral RNA sensors (e.g., MDA5) or inflammasome components, impacting antiviral defenses and autoimmune disorders.
Validated TRIM31 antibodies are essential for understanding its context-dependent functions and therapeutic potential. Researchers rely on specificity-confirmed antibodies (monoclonal/polyclonal) to dissect TRIM31’s mechanisms in disease models, aiding drug discovery and biomarker development.
×
