| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | Cab45; SDF-4 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human SDF4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SDF4抗体的模拟参考文献示例(实际文献需通过学术数据库检索确认)：
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1. **文献名称**：*SDF4 as a Novel Biomarker for Early Detection of Colorectal Cancer*
**作者**：Smith A, et al. (2020)
**摘要**：本研究通过免疫组化(IHC)和Western blot技术，验证了SDF4抗体在结直肠癌组织中的高特异性表达，表明SDF4可能作为早期诊断的生物标志物，并与患者预后显著相关。
2. **文献名称**：*Role of SDF4 in Calcium Signaling and Cardiovascular Disease*
**作者**：Johnson R, et al. (2018)
**摘要**：利用SDF4抗体检测发现，SDF4蛋白通过调控细胞内钙离子稳态参与动脉粥样硬化进程，提示其可能成为心血管疾病的潜在治疗靶点。
3. **文献名称**：*Development of a Monoclonal Antibody Against Human SDF4 for Functional Studies*
**作者**：Lee H, et al. (2015)
**摘要**：报道了一种高亲和力抗人SDF4单克隆抗体的开发，该抗体在ELISA、流式细胞术和免疫荧光中表现优异，为SDF4蛋白的分子机制研究提供了工具。
4. **文献名称**：*SDF4 Expression in Diabetic Retinopathy: Insights from Antibody-Based Proteomic Analysis*
**作者**：Wang Y, et al. (2022)
**摘要**：通过SDF4抗体的蛋白质组学分析，揭示了SDF4在糖尿病视网膜病变患者血清中的异常表达，提示其可能参与血管内皮功能障碍的病理过程。
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**注意**：以上内容为示例，实际文献需根据具体研究领域(如SDF4在癌症、代谢疾病或抗体开发中的应用)通过PubMed、Google Scholar等平台检索。
**Background of SDF4 Antibody**
SDF4 (Stromal Cell-Derived Factor 4), also known as Ca²⁺-binding protein 45 (Cab45), is a soluble protein primarily localized in the Golgi apparatus. It belongs to the CREC family of calcium-binding proteins and plays a critical role in regulating intracellular calcium-dependent processes, including protein sorting, secretion, and post-translational modifications. SDF4 is particularly implicated in the trafficking of secretory cargoes, such as growth factors and extracellular matrix components, by facilitating their packaging into vesicles.
Antibodies targeting SDF4 are valuable tools for studying its expression, localization, and functional interactions in cellular and tissue contexts. Research has linked SDF4 dysregulation to pathologies like cancer, cardiovascular diseases, and metabolic disorders, where altered secretory pathways contribute to disease progression. For instance, elevated SDF4 levels have been observed in certain cancers, suggesting its potential as a biomarker or therapeutic target.
SDF4 antibodies are widely used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to investigate its role in Golgi function, calcium signaling, and disease mechanisms. Recent studies also explore its involvement in autophagy and apoptosis, expanding its relevance in cellular homeostasis. As research advances, SDF4 antibodies continue to support mechanistic insights into secretory pathway dysfunctions and their clinical implications.
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