| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | 87U6; ARCND1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human GNAI3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于SENP5抗体的模拟参考文献示例(实际文献需通过学术数据库查询)：
1. **标题**: "SENP5 regulates SUMOylation dynamics and breast cancer progression"
**作者**: Zhang Y, et al.
**摘要**: 研究利用SENP5特异性抗体，验证其在乳腺癌细胞中调控SUMO修饰的作用，发现SENP5通过去SUMO化关键蛋白影响肿瘤转移，抗体用于Western blot和免疫共沉淀实验。
2. **标题**: "The role of SENP5 in mitotic chromosome stability"
**作者**: Li H, et al.
**摘要**: 通过SENP5抗体进行免疫荧光和流式细胞分析，证明SENP5通过调控有丝分裂相关蛋白的SUMO化水平维持染色体稳定性，抗体特异性经siRNA敲低实验验证。
3. **标题**: "SENP5-mediated deSUMOylation in cellular stress response"
**作者**: Wang X, et al.
**摘要**: 研究使用SENP5抗体探究其在氧化应激下的亚细胞定位变化，发现SENP5通过线粒体蛋白去SUMO化参与应激信号通路，抗体应用于组织样本的免疫组化分析。
4. **标题**: "Characterization of SENP5 knockout mice using specific antibodies"
**作者**: Kim S, et al.
**摘要**: 开发并验证SENP5多克隆抗体，用于检测基因敲除小鼠模型中SENP5蛋白缺失，揭示其在胚胎发育中的潜在作用，抗体经ELISA和免疫印迹严格验证特异性。
**备注**：以上为模拟示例，真实文献需通过PubMed、Web of Science等平台检索关键词(如SENP5 antibody、SUMO protease)。近期研究可能侧重其在癌症、神经疾病或代谢调控中的机制。
SENP5 (Sentrin/SUMO-specific protease 5) is a member of the SUMO-specific protease family, which plays a critical role in the dynamic regulation of SUMO (Small Ubiquitin-like Modifier) conjugation. SUMOylation, a reversible post-translational modification, regulates diverse cellular processes, including nuclear transport, transcriptional regulation, DNA repair, and stress responses. SENP5 specifically processes SUMO precursors to mature forms and deconjugates SUMO-modified substrates, influencing their localization, stability, or activity. It preferentially interacts with SUMO-2/3 isoforms over SUMO-1. reflecting its functional specialization in modulating poly-SUMO chains or SUMO paralog-specific signaling pathways.
Antibodies targeting SENP5 are essential tools for investigating its expression, subcellular distribution, and molecular interactions. These antibodies (e.g., rabbit or mouse monoclonal/polyclonal variants) are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation. Given the structural similarity among SENP family members, validation of SENP5 antibody specificity is crucial, often involving knockout cell lines or siRNA-mediated knockdown controls. SENP5 has been implicated in mitotic regulation, ribosome biogenesis, and cellular stress responses, with dysregulation linked to pathologies such as cancer and neurodegenerative diseases. Research using SENP5 antibodies continues to uncover its context-dependent roles in health and disease, emphasizing its potential as a therapeutic target.
×
