| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | SeP; SELP; SEPP; SEPP1 |
| WB Predicted band size | 43 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human SELENOP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SELENOP抗体的3篇参考文献及其摘要信息：
1. **文献名称**: "Selenoprotein P as a biomarker of selenium status in clinical trials with therapeutic implications"
**作者**: Schomburg L, et al.
**摘要**: 该研究评估了SELENOP抗体在测量血浆硒状态中的临床应用，证实其作为生物标志物在硒缺乏相关疾病(如甲状腺功能障碍和癌症)中的可靠性，并探讨了其在指导硒补充治疗中的潜力。
2. **文献名称**: "Antibody-based detection of Selenoprotein P in human plasma: Implications for type 2 diabetes risk assessment"
**作者**: Misu H, et al.
**摘要**: 研究开发了一种高特异性SELENOP抗体检测方法，发现2型糖尿病患者血浆SELENOP水平显著升高，提示其可能作为糖尿病早期诊断和氧化应激评估的生物标志物。
3. **文献名称**: "Selenoprotein P-neutralizing antibodies improve insulin sensitivity and reduce hepatic steatosis in a mouse model of metabolic syndrome"
**作者**: Takeshi Ueta, et al.
**摘要**: 通过动物实验证明，中和性SELENOP抗体可改善胰岛素抵抗和脂肪肝，揭示了靶向SELENOP在代谢综合征治疗中的潜在作用机制。
(注：以上文献信息为示例性内容，实际引用时建议通过PubMed或Web of Science核对原文信息。)
Selenoprotein P (SELENOP), encoded by the *SELENOP* gene, is a secreted glycoprotein primarily synthesized in the liver and widely expressed in vertebrates. It serves as a key transporter of selenium (Se), delivering this essential trace element to peripheral tissues via receptor-mediated endocytosis. SELENOP contains multiple selenocysteine residues, enabling it to function in antioxidant defense and redox regulation. Its role in maintaining systemic selenium homeostasis makes it critical for cellular functions, including thyroid hormone metabolism, immune response, and neurological health.
SELENOP antibodies are immunological tools developed to detect, quantify, or study the protein’s expression, localization, and interactions. These antibodies are pivotal in research on selenium-related pathologies, such as diabetes, cancer, and neurodegenerative disorders, where SELENOP dysregulation is implicated. For instance, elevated SELENOP levels are linked to insulin resistance, while deficiencies correlate with neurological impairments. Commercially available SELENOP antibodies (polyclonal or monoclonal) are validated for techniques like ELISA, Western blotting, and immunohistochemistry. Species-specific variants (human, mouse, rat) enable cross-disciplinary studies. Challenges include ensuring specificity due to SELENOP’s multiple isoforms and post-translational modifications. Recent advances in antibody engineering, such as recombinant antibodies, enhance sensitivity for low-abundance SELENOP detection in clinical samples. As a potential biomarker for selenium status and disease progression, SELENOP antibodies hold promise for diagnostic and therapeutic applications.
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