| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | AXAM2; SMT3IP2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human SENP2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SENP2抗体的3篇参考文献示例(注：文献信息为模拟示例，仅供参考)：
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1. **文献名称**：*SENP2 regulates mesenchymal stem cell differentiation by modulating Wnt/β-catenin signaling*
**作者**：Wang Y. et al.
**摘要**：研究通过Western blot和免疫共沉淀技术，利用SENP2抗体证实其在间充质干细胞分化中对β-catenin去SUMO化的调控作用，揭示SENP2通过影响Wnt信号通路决定细胞命运。
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2. **文献名称**：*SENP2 deletion in cardiomyocytes induces heart failure through destabilizing HIF-1α*
**作者**：Li X. et al.
**摘要**：通过构建心脏特异性SENP2敲除小鼠模型，结合免疫组化与Western blot(使用SENP2抗体)，证明SENP2通过去SUMO化稳定HIF-1α，维持心脏能量代谢平衡，缺失导致心力衰竭。
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3. **文献名称**：*SENP2-dependent SUMO modification of HDAC1 controls neuronal dendrite development*
**作者**：Zhang R. et al.
**摘要**：利用SENP2抗体进行免疫荧光染色和蛋白质分析，发现SENP2通过调控HDAC1的SUMO化状态影响组蛋白乙酰化，进而调节神经元树突发育，为神经发育障碍提供机制解释。
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**备注**：实际文献需通过PubMed、Web of Science等数据库检索确认，上述示例仅为满足格式要求的模拟内容。建议结合具体研究场景筛选最新文献。
The SENP2 (Sentrin/SUMO-specific protease 2) antibody is a crucial tool for studying the function and regulation of SENP2. a member of the SUMO protease family. SENP2 plays a pivotal role in the dynamic post-translational modification of proteins by SUMO (Small Ubiquitin-like Modifier). It catalyzes the cleavage of SUMO conjugates (deSUMOylation) to maintain cellular homeostasis, influencing processes like transcriptional regulation, nuclear transport, DNA repair, and cell cycle progression. Dysregulation of SENP2 has been implicated in cancer, neurodegenerative disorders, and cardiovascular diseases.
SENP2 antibodies are widely used in Western blotting, immunoprecipitation, and immunofluorescence to detect SENP2 expression, localization, and interaction partners. These antibodies are typically raised against specific epitopes of human SENP2. with validation in knockout cell lines or tissues to ensure specificity. Researchers rely on them to explore SENP2's role in modulating SUMOylation-dependent pathways, such as stabilizing tumor suppressors (e.g., PML) or regulating chromatin remodeling factors.
Given SENP2's dual roles in promoting or inhibiting disease pathways depending on cellular context, its antibodies are essential for dissecting its mechanistic contributions to pathophysiology and potential therapeutic targeting. Commercial SENP2 antibodies often include monoclonal and polyclonal variants optimized for diverse experimental applications.
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