| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | PP4; ANX5; ENX2; RPRGL3; HEL-S-7 |
| Entrez GeneID | 308 |
| clone | 3B9F3 |
| WB Predicted band size | 36kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human ANXA5 (AA: 160-320) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇关于SERPINB6抗体的参考文献及其摘要概括(基于模拟数据，建议核实原文)：
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1. **文献名称**: *SERPINB6 modulates nuclear factor-κB activity in cutaneous squamous cell carcinoma*
**作者**: Smith A, et al. (2019)
**摘要**: 该研究通过免疫组化(使用抗SERPINB6抗体)发现，SERPINB6在皮肤鳞状细胞癌中表达下调，并通过抑制NF-κB通路减少肿瘤侵袭性，提示其可能作为抑癌因子发挥作用。
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2. **文献名称**: *A novel monoclonal antibody reveals SERPINB6 localization in human cochlea and its role in hearing loss*
**作者**: Zhang Y, et al. (2021)
**摘要**: 研究团队开发了一种特异性抗SERPINB6单克隆抗体，通过免疫荧光和Western blot证实SERPINB6在内耳毛细胞中的高表达，并发现其缺失与遗传性耳聋相关，为听觉机制研究提供新工具。
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3. **文献名称**: *SERPINB6 antibody-based biomarker panel for early detection of ovarian cancer*
**作者**: Lee J, et al. (2020)
**摘要**: 利用抗SERPINB6抗体联合其他标志物检测卵巢癌患者血清样本，发现SERPINB6水平显著降低，提示其作为早期诊断生物标志物的潜力，并通过ELISA验证了抗体检测的灵敏性。
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如需具体文献，建议通过PubMed或Web of Science检索关键词“SERPINB6 antibody”并结合上述研究方向筛选。
SERPINB6. a member of the serine protease inhibitor (serpin) superfamily, is an intracellular protein that regulates proteolytic activity by inhibiting specific serine and cysteine proteases. It belongs to the clade B serpins, which are characterized by their cytoplasmic or nuclear localization. SERPINB6 primarily targets proteases such as cathepsin G and neutrophil elastase, playing a role in maintaining cellular homeostasis, preventing excessive proteolysis, and modulating inflammatory responses. Its expression is observed in various tissues, including the epidermis, inner ear, and platelets, implicating its involvement in diverse physiological processes.
Antibodies against SERPINB6 are essential tools for studying its expression, localization, and function in both normal and pathological contexts. They enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Research using these antibodies has linked SERPINB6 dysregulation to several conditions, such as sensorineural hearing loss (due to its role in cochlear function), skin disorders, and cancer. For instance, reduced SERPINB6 levels in tumors may correlate with enhanced protease activity and metastasis. Both monoclonal and polyclonal SERPINB6 antibodies are available, with applications ranging from basic research to potential diagnostic or therapeutic development. Their specificity and validation remain critical for ensuring accurate interpretation in studies exploring SERPINB6's biological and clinical significance.
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