| WB | 1/200-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | TPS2; tryptaseB; tryptaseC |
| WB Predicted band size | 31 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3-4条关于TPSB2抗体的模拟参考文献示例(文献信息为虚构，仅供格式参考)：
1. **"Tryptase β2 (TPSB2) as a Biomarker in Mast Cell Disorders"**
*作者：Smith A, et al.*
摘要：研究验证了TPSB2抗体在肥大细胞活化相关疾病(如过敏和肥大细胞增多症)中的特异性检测能力，表明其可作为临床诊断标志物。
2. **"Development of a Monoclonal Antibody for Human TPSB2 in Inflammatory Responses"**
*作者：Lee C, et al.*
摘要：报道了一种新型抗TPSB2单克隆抗体的开发，并证明其在炎症模型中对肥大细胞脱颗粒的定量分析具有高灵敏度和特异性。
3. **"Genetic Variants of TPSB2 and Their Association with Asthma Severity"**
*作者：Wang Y, et al.*
摘要：通过免疫组化结合TPSB2抗体，揭示了TPSB2基因多态性与哮喘患者气道重塑的相关性，提示其潜在治疗靶点价值。
4. **"TPSB2 Expression in Cardiovascular Diseases: Insights from Antibody-Based Profiling"**
*作者：Garcia R, et al.*
摘要：利用TPSB2抗体检测发现，肥大细胞来源的TPSB2在动脉粥样硬化斑块中高表达，可能参与血管炎症机制。
(注：上述文献为示例，实际研究中需引用真实发表的论文。)
The TPSB2 antibody targets tryptase beta-2 (TPSB2), a serine protease primarily expressed in mast cells. Tryptases, including TPSB2. are stored in mast cell granules and released upon activation, playing key roles in allergic responses, inflammation, and tissue remodeling. TPSB2 is notable for its stability and enzymatic activity, cleaving substrates like fibrinogen, neuropeptides, and cytokines. Its dysregulation is implicated in mast cell-associated disorders, such as asthma, anaphylaxis, urticaria, and mastocytosis, as well as tumor microenvironments where mast cells influence cancer progression.
The TPSB2 antibody is widely used in research to detect and quantify TPSB2 protein levels, aiding studies on mast cell activation, disease mechanisms, and biomarker identification. It is applied in techniques like immunohistochemistry, ELISA, and Western blotting. Commercially available antibodies vary in specificity, with some distinguishing TPSB2 from its isoform TPSAB1 (alpha/beta tryptase). Recent studies also explore TPSB2 as a therapeutic target, with inhibitors under investigation for inflammatory and fibrotic diseases.
In clinical diagnostics, TPSB2 antibodies help confirm systemic mastocytosis by detecting elevated serum tryptase. However, cross-reactivity with other tryptases requires careful validation. Overall, the TPSB2 antibody serves as a critical tool for advancing both basic research and translational applications in mast cell biology.
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