| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | TGP; hTGP |
| WB Predicted band size | 77 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human TGM4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与TGM4(Transglutaminase 4)抗体相关的文献示例及简要摘要：
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1. **文献名称**：*Transglutaminase 4 as a biomarker for prostate cancer progression*
**作者**：Smith A, et al.
**摘要**：该研究通过免疫组化和Western blot分析，发现TGM4在前列腺癌组织中高表达，且其表达水平与肿瘤侵袭性呈正相关。研究使用特异性TGM4抗体验证了其作为潜在预后标志物的可能性。
2. **文献名称**：*Role of TGM4 in sperm maturation and male fertility*
**作者**：Chen L, et al.
**摘要**：文章利用基因敲除小鼠模型和TGM4抗体进行功能研究，证实TGM4在精子膜蛋白交联中起关键作用，其缺失导致精子形态异常和雄性小鼠生育能力下降。
3. **文献名称**：*Autoantibodies against TGM4 in autoimmune disorders*
**作者**：Rodriguez M, et al.
**摘要**：该研究通过ELISA检测发现，部分自身免疫性疾病患者血清中存在TGM4自身抗体，提示TGM4可能参与异常免疫反应，为相关疾病的机制研究提供了新方向。
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**注**：以上文献信息为示例性内容，实际文献需通过PubMed、Google Scholar等平台检索确认。若需具体文献，建议补充更详细的研究背景或关键词。
The TGM4 antibody targets transglutaminase 4 (TGM4), a calcium-dependent enzyme belonging to the transglutaminase family. TGM4 is primarily expressed in the prostate gland and plays a role in cross-linking seminal fluid proteins, contributing to semen coagulation and sperm motility. Unlike other transglutaminases (e.g., TGM2 in celiac disease), TGM4 has limited tissue distribution, with high specificity to reproductive tissues. Research on TGM4 antibodies has gained interest due to their potential applications in studying prostate physiology, male infertility, and prostate cancer. In prostate cancer, aberrant TGM4 expression has been linked to tumor progression and metastasis, making it a candidate biomarker or therapeutic target.
Commercially available TGM4 antibodies are typically monoclonal or polyclonal, developed using recombinant TGM4 protein fragments. They are used in techniques like Western blotting, immunohistochemistry, and ELISA to detect TGM4 expression in tissue samples or biological fluids. Challenges in TGM4 antibody development include ensuring specificity, as cross-reactivity with other transglutaminases can occur due to structural similarities. Recent studies also explore autoantibodies against TGM4 in autoimmune contexts, though their clinical relevance remains under investigation. Overall, TGM4 antibodies serve as critical tools for unraveling the enzyme's biological roles and its implications in reproductive and oncological research.
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