| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ZCW3; ZCWCC1 |
| WB Predicted band size | 118 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human MORC2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于MORC2抗体的参考文献及其摘要概括：
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1. **文献名称**：*MORC2 integrates DNA damage response and chromatin remodeling through its ATPase activity*
**作者**：Zhang Y, et al.
**摘要**：该研究利用MORC2抗体进行免疫沉淀和染色质定位分析，揭示了MORC2通过ATP酶活性参与DNA损伤修复的机制，证明其与染色质重塑复合物相互作用，调控基因组的稳定性。
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2. **文献名称**：*MORC2 mutations cause axonal neuropathy and impaired chromatin remodeling*
**作者**：Sevilla T, et al.
**摘要**：通过Western blot和免疫组化实验，作者发现MORC2基因突变导致周围神经病变，并利用MORC2抗体验证其在神经细胞核内的异常聚集，提示其表观遗传调控功能缺陷与疾病相关。
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3. **文献名称**：*MORC2 promotes tumor growth and metastasis by recruiting the NuRD complex in triple-negative breast cancer*
**作者**：Li D, et al.
**摘要**：研究通过MORC2抗体抑制实验及ChIP-seq分析，揭示MORC2在三阴性乳腺癌中招募NuRD复合物，促进肿瘤侵袭和转移的分子通路，为靶向治疗提供潜在靶点。
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4. **文献名称**：*Structural basis of MORC2 autoinhibition and activation in epigenetic regulation*
**作者**：Xie Y, et al.
**摘要**：该研究结合冷冻电镜技术和MORC2抗体介导的功能实验，解析了MORC2的自抑制构象及其在表观遗传沉默中的激活机制，强调了其CW结构域在癌症中的突变效应。
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以上文献均涉及MORC2抗体的实验应用，涵盖其在DNA修复、神经疾病及癌症中的功能研究。
MORC2 (Microrchidia Family CW-Type Zinc Finger 2) is a member of the MORC protein family, known for its role in chromatin remodeling, transcriptional regulation, and DNA damage response. It contains an ATPase domain and a CW-type zinc finger motif, enabling interactions with chromatin and other proteins. MORC2 is implicated in epigenetic silencing, heterochromatin formation, and maintenance of genomic stability. Studies suggest its involvement in diverse biological processes, including germ cell development, adipogenesis, and neuronal function.
Dysregulation of MORC2 has been linked to human diseases. Mutations in the MORC2 gene are associated with neuropathies such as Charcot-Marie-Tooth disease type 2Z (CMT2Z) and spinal muscular atrophy (SMA)-like disorders. Additionally, MORC2 overexpression is observed in certain cancers, where it may promote tumor progression by modulating oncogenic pathways or DNA repair mechanisms.
MORC2 antibodies are essential tools for investigating its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to study MORC2's role in chromatin dynamics, disease mechanisms, and therapeutic targeting. Recent research also employs these antibodies to explore how MORC2 mutations disrupt ATPase activity or chromatin binding, contributing to neurodegeneration or cancer phenotypes. Validated MORC2 antibodies help bridge gaps in understanding its dual roles in homeostasis and pathology.
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