| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | YL8 |
| WB Predicted band size | 24 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于RAB11A抗体的参考文献示例(注：文献为示例性内容，实际引用时请核实来源)：
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1. **文献名称**：Rab11 regulates endocytic protein sorting and antibody secretion in epithelial cells
**作者**：Chen X, et al.
**摘要**：该研究利用RAB11A抗体通过免疫荧光和Western blot技术，揭示了RAB11A在上皮细胞内吞和抗体分泌过程中的关键作用，表明其通过调控囊泡运输影响蛋白质定向分泌。
2. **文献名称**：Rab11a-dependent exocytosis of intracellular vesicles facilitates influenza virus replication
**作者**：Lakdawala SS, et al.
**摘要**：通过RAB11A抗体标记和功能抑制实验，研究发现流感病毒利用RAB11A介导的囊泡运输系统完成病毒颗粒的组装与释放，为抗病毒靶点提供理论依据。
3. **文献名称**：Rab11a controls cell shape via Cdc42 activation at the recycling endosome
**作者**：Matsui T, et al.
**摘要**：使用RAB11A抗体进行共聚焦成像，发现RAB11A通过回收内体激活Cdc42信号通路，调控细胞形态和迁移，揭示了其在细胞动力学中的新机制。
4. **文献名称**：Role of Rab11a in the biosynthetic route of the neuronal glutamate transporter EAAC1
**作者**：González MI, et al.
**摘要**：研究通过RAB11A抗体结合免疫沉淀技术，证明RAB11A参与神经元中EAAC1转运体的再循环过程，影响突触谷氨酸稳态及神经信号传递。
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**注意**：以上文献标题及内容为基于领域知识的示例，实际引用时请通过学术数据库(如PubMed、Google Scholar)核实具体文献的准确性及发表信息。
**Background of RAB11A Antibody**
RAB11A, a member of the Ras-associated binding (RAB) GTPase family, plays a critical role in regulating intracellular vesicular trafficking, particularly in recycling endosomes that shuttle cargo between the trans-Golgi network, endosomes, and the plasma membrane. It is essential for processes like cytokinesis, cell migration, receptor recycling, and autophagy. Dysregulation of RAB11A has been linked to cancers, neurodegenerative disorders, and viral infections, highlighting its biomedical relevance.
RAB11A antibodies are crucial tools for studying its expression, localization, and functional interactions. These antibodies, often developed in rabbits or mice, target specific epitopes of the RAB11A protein and are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation. Their specificity is validated through knockout controls or siRNA-mediated silencing to confirm signal loss.
Research using RAB11A antibodies has revealed its dynamic GTP/GDP-dependent conformational changes, which regulate its binding to effector proteins. Such studies also explore its role in pathological contexts, such as tumor metastasis (e.g., altered EGFR trafficking) or impaired synaptic vesicle recycling in neurological diseases. Additionally, RAB11A antibodies aid in diagnosing diseases with trafficking defects or evaluating therapeutic strategies targeting vesicular transport pathways. Continued development of high-affinity, isoform-specific antibodies remains vital for dissecting RAB11A's diverse cellular roles.
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