Rabbit Polyclonal ABHD14B Antibody

The ABHD14B (α/β-hydrolase domain-containing protein 14B) antibody is a tool used to study the poorly characterized ABHD14B enzyme, part of the α/β-hydrolase superfamily. This protein family shares a conserved catalytic triad (Ser-Asp-His) and structural motifs, often linked to metabolic processes like lipid hydrolysis. ABHD14B’s exact biological role remains unclear, but it is hypothesized to participate in lipid metabolism or cellular signaling due to its hydrolase domain. It shows tissue-specific expression, with higher levels detected in the liver, kidney, and brain, suggesting organ-specific functions. Research using ABHD14B antibodies focuses on elucidating its substrate specificity, enzymatic activity, and involvement in diseases such as cancer or neurological disorders. These antibodies, typically monoclonal or polyclonal, enable techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect protein expression, localization, and interaction partners. Validation via knockout controls or siRNA knockdown is critical to confirm specificity. Commercial availability of ABHD14B antibodies supports broader studies into its physiological relevance, though limited literature necessitates cautious interpretation of findings. Overall, this antibody serves as a key reagent in unraveling ABHD14B’s role in cellular processes and potential therapeutic applications.