Rabbit Polyclonal WDFY2 Antibody

The WDFY2 (WD repeat and FYVE domain-containing protein 2) antibody is a tool used to study the WDFY2 protein, a member of the WDFY family implicated in cellular processes such as autophagy and membrane trafficking. WDFY2 contains conserved WD40 repeats, which facilitate protein-protein interactions, and a FYVE domain that binds phosphatidylinositol 3-phosphate (PI3P), enabling its association with endosomal and autophagosomal membranes. Research suggests WDFY2 plays a role in autophagosome-lysosome fusion and cargo selection during autophagy, a critical pathway for cellular homeostasis. Dysregulation of WDFY2 has been linked to neurodegenerative diseases, cancer, and immune disorders, though its exact mechanistic contributions remain under investigation. The WDFY2 antibody is widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect protein expression, localization, and interactions in various tissues and cell lines. Its development and validation often involve specificity checks using knockout controls or siRNA-mediated knockdown. Commercial availability from multiple antibody suppliers has facilitated its use in both basic and translational research, particularly in studies exploring autophagy-related pathologies or organelle dynamics. However, variability in antibody performance across experimental conditions underscores the need for rigorous optimization in individual applications.