Rabbit Polyclonal ZBTB44 Antibody

The ZBTB44 antibody is a tool used to detect ZBTB44. a member of the zinc finger and BTB domain-containing (ZBTB) protein family. ZBTB44 functions as a transcription regulator, characterized by its N-terminal BTB domain for protein-protein interactions and C-terminal zinc finger motifs for DNA binding. It is implicated in diverse cellular processes, including cell proliferation, differentiation, and apoptosis, often acting as a transcriptional repressor. Research highlights its role in cancer biology, where it may act as a tumor suppressor or oncogene depending on context. For example, ZBTB44 has been linked to pathways like Wnt and TGF-β, and its dysregulation is observed in malignancies such as colorectal cancer and leukemia. The antibody is widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study ZBTB44 expression, localization, and interactions. Commercially available clones (e.g., rabbit polyclonal or mouse monoclonal antibodies) are validated for specificity using knockout controls. Studies employing ZBTB44 antibodies have also explored its involvement in immune regulation and epigenetic silencing, underscoring its potential as a biomarker or therapeutic target. Despite progress, its precise mechanisms remain under investigation, necessitating further research to clarify its context-dependent roles in health and disease.