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Rabbit Polyclonal LRIF1 Antibody

  • 中文名: LRIF1抗体
  • 别    名: RIF1; C1orf103
货号: IPDX09398
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesRIF1; C1orf103
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human LRIF1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是基于现有知识推测的与LRIF1相关的文献示例(注:LRIF1研究较为小众,以下内容为假设性示例,建议通过学术数据库验证实际文献):

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1. **标题**:*LRIF1 regulates chromatin remodeling and DNA repair through interaction with histone modifiers*

**作者**:Smith J, et al.

**摘要**:本研究揭示了LRIF1在DNA损伤修复中的作用,通过免疫共沉淀(Co-IP)和Western blot技术,利用特异性LRIF1抗体证明其与组蛋白乙酰转移酶复合物的相互作用,提示其在染色质动态调控中的关键功能。

2. **标题**:*Development of a monoclonal antibody targeting LRIF1 for cancer biomarker studies*

**作者**:Chen L, et al.

**摘要**:报道了一种新型抗LRIF1单克隆抗体的开发与验证,该抗体在多种癌细胞系中显示出高特异性,可用于免疫组化(IHC)和流式细胞术,为LRIF1在肿瘤中的表达模式研究提供了工具。

3. **标题**:*LRIF1 deficiency disrupts neural stem cell differentiation in vivo*

**作者**:Wang Y, et al.

**摘要**:通过构建LRIF1敲除小鼠模型,结合免疫荧光(使用LRIF1抗体)和RNA测序,发现LRIF1缺失导致神经干细胞分化异常,强调其在神经发育中的调控作用。

4. **标题**:*LRIF1 antibody-based screening identifies novel interactors in the p53 signaling pathway*

**作者**:Garcia R, et al.

**摘要**:利用LRIF1抗体进行蛋白质组学筛选,鉴定出多个与p53通路相关的新型相互作用蛋白,提示LRIF1可能通过调控p53稳定性参与肿瘤抑制机制。

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**建议**:

- 实际文献可能较少,建议通过PubMed或Google Scholar以“LRIF1 antibody”或“LRIF1 protein interaction”为关键词检索最新研究。

- 若LRIF1为特定物种(如人类/小鼠),需在检索时限定物种名称以提高准确性。

背景信息

LRIF1 (Leucine-Rich Repeats and Immunoglobulin-like Domains Protein 1) is a protein containing structural motifs associated with mediating protein-protein interactions, such as leucine-rich repeats and immunoglobulin-like domains. These features suggest roles in cellular signaling, structural organization, or regulatory processes. While its precise biological functions remain under investigation, LRIF1 has been implicated in transcriptional regulation, chromatin remodeling, and potential involvement in DNA damage response pathways. Dysregulation of LRIF1 has been linked to certain cancers, where altered expression may correlate with tumorigenesis or metastasis. The LRIF1 antibody is a critical reagent designed to detect and study this protein in research contexts. It is widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to analyze LRIF1 expression patterns, subcellular localization, and interaction networks across tissues or disease states. This tool has facilitated insights into LRIF1’s role in cellular homeostasis, stress responses, and disease mechanisms. Recent studies employ LRIF1 antibodies to explore its association with oncogenic pathways or as a potential biomarker in diagnostic applications. By enabling precise detection, the antibody supports both basic research into LRIF1’s molecular functions and translational efforts to evaluate its therapeutic relevance. Its development underscores the growing interest in understanding proteins with modular domains that interface with multiple signaling cascades.

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