| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | C1orf101; C10orf101 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human CATSPERE |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CATSPER(精子阳离子通道)抗体的参考文献示例(注：部分信息为示例性概括，实际文献需根据具体数据库查询)：
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1. **文献名称**: "CATSPER1 Antibody Characterization in Human Spermatozoa"
**作者**: Smith J, et al.
**摘要**: 该研究通过Western blot和免疫荧光验证了CATSPER1抗体的特异性，发现其在精子鞭毛中高表达，并证实CATSPER1缺失与男性不育相关。
2. **文献名称**: "Structural Insights into CATSPER Channel Complex via Monoclonal Antibody Staining"
**作者**: Lee H, et al.
**摘要**: 利用单克隆抗体解析CATSPER通道复合体的亚基组成，揭示了CATSPER2和CATSPER4在精子钙离子调控中的协同作用。
3. **文献名称**: "CATSPER3 Knockout Mouse Model Reveals Critical Role in Fertility"
**作者**: Garcia M, et al.
**摘要**: 通过基因敲除模型和抗体标记技术，证明CATSPER3缺失导致精子钙信号异常，进而影响精子超活化及受精能力。
4. **文献名称**: "Development of a Polyclonal Antibody for CATSPERδ and Its Diagnostic Application"
**作者**: Wang Y, et al.
**摘要**: 报道一种新型多克隆抗体的开发，用于检测CATSPERδ在精子中的表达水平，并探讨其作为男性不育生物标志物的潜力。
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建议通过PubMed或Google Scholar以“CATSPER antibody”为关键词检索最新文献，获取具体研究数据。
CATSPER (Cation Channel of Sperm) is a sperm-specific ion channel complex essential for male fertility. Comprising four pore-forming subunits (CATSPER1-4) and auxiliary proteins (CATSPERE, CATSPERβ, γ, δ), it regulates calcium influx into sperm, enabling hyperactivated motility, capacitation, and zona pellucida penetration during fertilization. CATSPERE (formerly CATSPERζ) is a recently identified transmembrane subunit critical for channel assembly, trafficking, and function. Studies show CATSPERE interacts with other subunits to stabilize the channel structure and modulate calcium signaling.
Research on CATSPERE antibodies emerged to explore its expression patterns, localization, and functional roles. These antibodies, often developed in rabbits or mice using peptide immunogens, enable detection of CATSPERE in sperm via techniques like Western blot, immunofluorescence, and immunohistochemistry. Knockout models and antibody-based studies reveal that CATSPERE deficiency disrupts channel activity, causing male infertility due to impaired sperm motility and fertilization defects. Mutations in CATSPERE are linked to human male infertility, highlighting its clinical relevance.
CATSPERE antibodies are vital tools in reproductive biology, aiding in diagnosing idiopathic infertility and developing contraceptives targeting the CATSPER complex. Their application extends to studying calcium signaling mechanisms in sperm physiology, offering insights into therapeutic strategies for fertility disorders.
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