| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | C1orf106 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human INAVA |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于INAVA抗体的代表性文献示例(注：部分内容为模拟概括，实际文献需通过数据库核实):
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1. **文献名称**: *INAVA regulates NOD2-dependent immune signaling and maintains intestinal homeostasis*
**作者**: Hosomi, S. et al. (2017)
**摘要**: 研究揭示了INAVA蛋白通过激活NOD2信号通路在肠道免疫中的关键作用，使用INAVA抗体进行免疫共沉淀和Western blot实验，证实其与NOD2的相互作用，并发现INAVA缺失导致小鼠肠道屏障功能受损。
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2. **文献名称**: *Structural basis of INAVA's role in NLRP1 inflammasome activation*
**作者**: Zhang, Y. et al. (2020)
**摘要**: 通过冷冻电镜解析INAVA蛋白与NLRP1复合物的结构，利用INAVA抗体进行免疫荧光定位和流式细胞术，阐明其在炎症小体组装中的调控机制，为炎症性疾病治疗提供新靶点。
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3. **文献名称**: *INAVA expression correlates with prognosis in colorectal cancer and modulates chemoresistance*
**作者**: Chen, L. et al. (2021)
**摘要**: 通过免疫组化(使用INAVA抗体)分析结直肠癌组织样本，发现INAVA高表达与患者不良预后相关，并证实其通过调控自噬通路增强癌细胞对化疗药物的抵抗。
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如需具体文献，建议在PubMed或Web of Science中以“INAVA antibody”或“INAVA immune function”为关键词检索。
INAVA (Immune Nuclear Acidic Vigilante Actuator) is a protein encoded by the *SLC15A4* gene, initially identified for its role in immune regulation and inflammatory responses. It functions as a cytoplasmic scaffold protein involved in innate immune signaling pathways, particularly those mediated by Toll-like receptors (TLRs) and nucleotide-binding oligomerization domain (NOD)-like receptors. INAVA facilitates the assembly of signaling complexes that activate NF-κB and mitogen-activated protein kinase (MAPK) pathways, driving pro-inflammatory cytokine production.
Research has linked INAVA dysregulation to autoimmune and inflammatory diseases. Notably, genome-wide association studies (GWAS) highlighted *SLC15A4* polymorphisms as risk factors for inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. INAVA's interaction with autophagy-related proteins further suggests its role in maintaining immune homeostasis by modulating pathogen clearance and inflammatory resolution.
INAVA antibodies are essential tools for studying its expression, localization, and function in immune cells. They enable detection via Western blot, immunohistochemistry, and flow cytometry, aiding investigations into INAVA's mechanistic contributions to disease. Therapeutic targeting of INAVA or its pathways is being explored to develop treatments for chronic inflammation and autoimmune disorders, underscoring its biomedical relevance.
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