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Rabbit Polyclonal CCDC181 Antibody

  • 中文名: CCDC181抗体
  • 别    名: C1orf114
货号: IPDX09401
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

参考文献

以下是假设性的关于CCDC181抗体的参考文献示例(仅供学术参考,非真实文献):

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1. **文献名称**: "CCDC181 Localizes to Sperm Flagella and Its Antibody-Based Disruption Causes Motility Defects"

**作者**: Smith et al. (2020)

**摘要**: 本研究利用抗CCDC181抗体通过免疫荧光技术证实了该蛋白在人类精子鞭毛轴丝中的特异性定位。实验表明,抗体介导的CCDC181功能抑制会导致精子运动能力显著下降,提示其在男性不育症中的潜在作用。

2. **文献名称**: "Expression Profiling of CCDC181 in Ciliopathies Using Monoclonal Antibodies"

**作者**: Zhang et al. (2018)

**摘要**: 通过开发高特异性CCDC181单克隆抗体,研究者分析了该蛋白在纤毛相关疾病患者组织中的表达模式。Western blot和免疫组化结果显示,CCDC181在原发性纤毛运动障碍(PCD)患者中表达异常,提示其与纤毛结构功能密切相关。

3. **文献名称**: "CCDC181 Knockout Mouse Model Reveals Its Role in Spermatogenesis via Antibody-Based Detection"

**作者**: Braun et al. (2022)

**摘要**: 研究构建了CCDC181基因敲除小鼠模型,并利用多克隆抗体检测蛋白表达缺失。结果显示,CCDC181缺失导致精子发生停滞及睾丸形态异常,证实其对哺乳动物生殖细胞发育的关键调控作用。

4. **文献名称**: "CCDC181 as a Novel Biomarker in Cancer: Insights from Antibody-Mediated Pathway Analysis"

**作者**: Johnson & Lee (2021)

**摘要**: 基于抗CCDC181的免疫沉淀技术,本研究筛选了其在多种癌细胞系中的相互作用蛋白网络,发现其与微管稳定性相关通路存在显著关联,为癌症靶向治疗提供了新方向。

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注:以上文献为虚构示例,实际研究中请通过学术数据库(如PubMed、Web of Science)检索真实发表的文献。

背景信息

The CCDC181 (Coiled-Coil Domain Containing 181) antibody is a tool used to study the CCDC181 protein, encoded by the CCDC181 gene located on human chromosome 14. This protein belongs to the family of coiled-coil domain-containing proteins, which are often involved in structural or regulatory roles in cellular processes. CCDC181 is particularly associated with cilia and flagella functions, playing a critical role in sperm motility and ciliary assembly. Research suggests it is highly expressed in testicular tissues, specifically in spermatogenic cells, where it contributes to the structural integrity of the sperm flagellum. Dysregulation of CCDC181 has been linked to male infertility due to impaired sperm movement (asthenozoospermia). The antibody is utilized in techniques like immunohistochemistry, Western blotting, and immunofluorescence to detect protein expression, localization, and interactions in reproductive biology studies. Its development aids in understanding molecular mechanisms underlying ciliopathies and fertility disorders. However, detailed functional studies of CCDC181 remain limited, highlighting the need for further investigation into its signaling pathways and potential therapeutic targets.

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