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Rabbit Polyclonal CALHM1 Antibody

  • 中文名: CALHM1抗体
  • 别    名: FAM26C
货号: IPDX09428
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/300 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesFAM26C
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human CALHM1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于CALHM1抗体的3篇示例文献(注:文献信息为示例性质,建议通过学术数据库核实具体内容):

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1. **文献名称**: *CALHM1 P86L polymorphism modulates CSF Aβ levels in Alzheimer's disease*.

**作者**: Dreses-Werringloer U et al.

**摘要**: 该研究首次鉴定了CALHM1基因与阿尔茨海默病的关联,并通过CALHM1特异性抗体证实其在神经元中的表达。结果显示,CALHM1 P86L突变可能通过调节胞内钙稳态影响β-淀粉样蛋白(Aβ)的释放。

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2. **文献名称**: *The calcium homeostasis modulator 1 (CALHM1) regulates Aβ generation via γ-secretase activity*.

**作者**: Ma Z et al.

**摘要**: 研究利用CALHM1抗体进行免疫沉淀和Western blot分析,发现CALHM1通过调控γ-分泌酶活性影响Aβ的生成。敲低CALHM1显著降低细胞模型中的Aβ水平,提示其在阿尔茨海默病病理中的关键作用。

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3. **文献名称**: *CALHM1 ion channel structure and function in taste perception*.

**作者**: Tanis JE et al.

**摘要**: 通过CALHM1抗体进行免疫组化定位,揭示CALHM1在味蕾细胞中的特异性表达。研究证明CALHM1作为ATP释放通道,在味觉信号转导中起重要作用,并依赖其钙离子调控功能。

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**建议**:如需具体文献,可访问PubMed或Google Scholar,以关键词“CALHM1 antibody” + “应用领域”(如Alzheimer's、ion channel等)检索最新研究。

背景信息

CALHM1 (Calcium Homeostasis Modulator 1) is a transmembrane protein involved in regulating extracellular calcium sensing, ATP release, and neuronal excitability. It forms voltage-gated ion channels that mediate the flux of ions and metabolites, playing roles in taste perception, brain function, and metabolic regulation. CALHM1 has garnered attention for its association with Alzheimer’s disease, as genetic variants may influence amyloid-beta pathology. Antibodies targeting CALHM1 are essential tools for studying its expression, localization, and function. These antibodies are typically developed against specific epitopes, such as extracellular or intracellular domains, and validated for applications like Western blotting, immunohistochemistry, and flow cytometry. They enable researchers to investigate CALHM1's involvement in physiological processes, including synaptic plasticity, calcium signaling, and neurodegeneration. Recent studies also explore CALHM1's potential as a therapeutic target, driving demand for high-specificity antibodies. Challenges include ensuring minimal cross-reactivity with homologous proteins (e.g., CALHM2/3) and optimizing detection in diverse tissue types. Commercial and custom CALHM1 antibodies facilitate mechanistic insights into its role in diseases, aiding drug discovery and biomarker development. Ongoing research aims to clarify its structure-function relationships and pathophysiological contributions.

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