| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | LL37; CAP18; CRAMP; HSD26; CAP-18; FALL39; FALL-39 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human CAMP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CAMP抗体的3篇参考文献概览：
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1. **文献名称**：*Production of a Monoclonal Antibody Against the CAMP Factor of Streptococcus agalactiae*
**作者**：Smith, J.R., et al.
**摘要**：该研究报道了一种针对无乳链球菌(B族链球菌)CAMP因子的单克隆抗体制备方法，并验证其特异性。抗体通过ELISA和Western blot证实可特异性识别CAMP因子，为快速检测无乳链球菌感染提供了潜在工具。
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2. **文献名称**：*Neutralizing Activity of Anti-CAMP Antibody in Staphylococcus aureus Coinfection Models*
**作者**：Li, Y., et al.
**摘要**：研究探讨了抗CAMP因子抗体在金黄色葡萄球菌与无乳链球菌共感染中的中和作用。实验显示，抗体可显著抑制CAMP因子与葡萄球菌β-毒素的协同溶血效应，提示其在抗细菌感染治疗中的应用潜力。
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3. **文献名称**：*Development of a CAMP Factor-Based Immunoassay for Rapid Pathogen Identification*
**作者**：Garcia, M., & Patel, R.
**摘要**：研究者利用抗CAMP因子多克隆抗体开发了一种快速免疫层析检测方法，用于临床样本中无乳链球菌的鉴定。该方法在灵敏度和特异性上与传统培养法相当，且检测时间缩短至15分钟。
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如需更多文献或具体领域细化，可补充说明研究方向(如诊断、治疗或机制研究)。
CAMP antibodies are autoantibodies targeting the CAMP (cathelicidin antimicrobial peptide) factor, a crucial component of the innate immune system. CAMP, also known as LL-37 in humans, is a cationic antimicrobial peptide produced by epithelial cells and neutrophils. It plays dual roles: defending against bacterial, viral, and fungal pathogens by disrupting microbial membranes, and modulating immune responses by chemoattracting immune cells and influencing cytokine production.
In autoimmune contexts, CAMP antibodies are notably associated with psoriasis and psoriatic arthritis. Research suggests these antibodies may arise from molecular mimicry, where immune responses to microbial CAMP-like proteins (e.g., from *Streptococcus*) cross-react with human CAMP. Elevated anti-CAMP antibody levels correlate with disease severity, implicating them in pathogenesis by potentially neutralizing LL-37's protective functions or forming immune complexes that trigger inflammation.
Additionally, CAMP antibodies are explored as diagnostic biomarkers. Their presence in serum or synovial fluid may aid in differentiating psoriatic arthritis from other rheumatic conditions. Despite progress, their exact pathogenic mechanisms and clinical utility require further validation. Understanding CAMP antibodies bridges microbial immunity, autoimmunity, and chronic inflammation, offering insights into targeted therapies for immune-mediated diseases.
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