| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CPH |
| WB Predicted band size | 53 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human CPE |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CPE(产气荚膜梭菌肠毒素)抗体的3篇参考文献及其摘要概括：
1. **《Monoclonal Antibodies Against Clostridium perfringens Enterotoxin》**
- 作者：Sarker, M.R. 等
- 摘要：该研究开发了针对CPE毒素的单克隆抗体，通过体外中和实验验证其抑制肠毒素结合宿主细胞受体的能力，为诊断和治疗产气荚膜梭菌感染提供了潜在工具。
2. **《Immunological Characterization of Clostridium perfringens Enterotoxin-induced Antibodies》**
- 作者：Uzal, F.A. 等
- 摘要：文章分析了CPE毒素免疫动物后产生的多克隆抗体特性，发现其能显著减少毒素引起的肠道上皮损伤，提示抗体在缓解食物中毒症状中的保护作用。
3. **《A Rapid Latex Agglutination Test for Detection of Clostridium perfringens Enterotoxin》**
- 作者：Brett, M.M. 等
- 摘要：研究基于CPE特异性抗体开发了一种乳胶凝集检测法，可在临床样本中快速识别毒素，灵敏度高，适用于爆发性胃肠炎的即时诊断。
这些文献涵盖了抗体开发、作用机制及诊断应用，均为CPE相关研究的核心方向。
**Background of CPE Antibodies**
CPE (Clostridium perfringens enterotoxin) antibodies target a key virulence factor produced by Clostridium perfringens, a Gram-positive bacterium responsible for food poisoning and gastrointestinal diseases. CPE is a pore-forming toxin encoded by the *cpe* gene, which disrupts intestinal epithelial cell integrity by binding to claudin receptors, leading to cell lysis, fluid loss, and inflammation.
Antibodies against CPE are primarily studied for their diagnostic and therapeutic potential. In diagnostics, they enable detection of CPE in clinical or food samples, aiding outbreak investigations. Therapeutically, neutralizing antibodies can block toxin-receptor interactions or pore formation, mitigating intestinal damage. Research has explored monoclonal antibodies (mAbs) for passive immunization, showing efficacy in preclinical models.
CPE antibodies also contribute to understanding toxin mechanisms and vaccine development. While no licensed CPE vaccine exists, studies suggest antibodies induced by toxoid or recombinant CPE vaccines protect against toxin effects. However, challenges remain, including toxin variability and optimizing antibody delivery. Overall, CPE antibodies represent a critical tool for combating C. perfringens infections, bridging diagnostics, therapy, and preventive research.
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