| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CARPX1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human CA11 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CA11抗体的示例参考文献(内容为模拟示例，实际文献请通过学术数据库查询)：
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1. **文献名称**: "CA11 as a Novel Biomarker for Ovarian Cancer: Diagnostic Implications"
**作者**: Smith A, et al.
**摘要**: 研究探讨了CA11抗体在卵巢癌组织中的高表达，证实其作为潜在诊断标志物的敏感性，与患者预后呈负相关。
2. **文献名称**: "Characterization of CA11 Antibody in Pancreatic Ductal Adenocarcinoma"
**作者**: Lee JH, et al.
**摘要**: 通过免疫组化分析CA11在胰腺导管腺癌中的表达，发现其与肿瘤侵袭性相关，提示其在靶向治疗中的应用价值。
3. **文献名称**: "CA11 Autoantibodies in Autoimmune Diseases: A Cohort Study"
**作者**: García R, et al.
**摘要**: 首次报道CA11抗体在系统性红斑狼疮患者血清中的存在，可能参与自身免疫反应的病理机制。
4. **文献名称**: "Development of a High-Specificity CA11 Monoclonal Antibody for Research Use"
**作者**: Wang Y, et al.
**摘要**: 描述了一种新型CA11单克隆抗体的制备与验证，证明其在Western blot和免疫荧光中的高特异性。
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**提示**：实际文献可通过PubMed或Google Scholar以关键词“CA11 antibody”、“Carbonic Anhydrase XI”或“CA11 biomarker”检索。注意区分不同物种(人/鼠)及研究领域(癌症/自身免疫病)。
**Background of CA11 Antibody**
The CA11 antibody targets carbonic anhydrase XI (CA11), a member of the carbonic anhydrase (CA) enzyme family involved in pH regulation, CO₂ homeostasis, and ion transport. CA11. encoded by the *CA11* gene, is a secreted glycoprotein with a unique structure, featuring a CA catalytic domain and a proteoglycan-like region. While its exact physiological role remains less characterized compared to other CA isoforms (e.g., CA9 or CA12), CA11 is implicated in extracellular matrix remodeling, cell adhesion, and possibly tumorigenesis.
CA11 expression has been detected in various tissues, including the brain, kidney, and reproductive organs, with elevated levels observed in certain cancers, such as renal cell carcinoma and glioblastoma. This tumor-associated expression suggests its potential as a biomarker or therapeutic target. CA11 antibodies are primarily utilized in research to study protein localization, expression patterns, and functional roles in disease models. They enable techniques like immunohistochemistry, Western blotting, and ELISA, aiding in the exploration of CA11's involvement in cancer progression, neurological disorders, and metabolic pathways.
Despite progress, challenges persist in clarifying CA11's precise mechanisms and clinical relevance. Ongoing studies aim to validate its diagnostic utility and assess its suitability for antibody-based therapies or imaging agents in oncology.
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