| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/500-1/1000 | Human,Mouse,Rat |
| Aliases | CAMKKA |
| WB Predicted band size | 56 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human CAMKK1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CAMKK1抗体的3篇参考文献示例(注：内容为模拟，实际文献需通过数据库查询验证)：
1. **文献名称**：*"Characterization of a novel monoclonal antibody against human CAMKK1 and its application in detecting protein expression in neuronal tissues"*
**作者**：Sakagami H, et al.
**摘要**：本研究开发了一种特异性识别CAMKK1的单克隆抗体，并验证其在Western blot和免疫组化中的应用。结果显示，CAMKK1在大脑海马区神经元中高表达，提示其在突触可塑性中的潜在作用。
2. **文献名称**：*"CAMKK1-AMPK signaling in cancer metabolism: Insights from antibody-based knockdown experiments"*
**作者**：Anderson KA, et al.
**摘要**：通过使用CAMKK1抗体进行功能研究，发现抑制CAMKK1可阻断AMPK活化，进而抑制肿瘤细胞的糖酵解和增殖，表明其作为癌症治疗靶点的潜力。
3. **文献名称**：*"Differential regulation of CAMKK1 isoforms in metabolic stress: A study using isoform-specific antibodies"*
**作者**：Tokumitsu H, Inuzuka H.
**摘要**：通过亚型特异性抗体分析，揭示了CAMKK1在不同代谢应激条件下的表达变化，并证实其在肝脏脂质代谢调控中的关键作用。
如需具体文献，建议通过PubMed或Google Scholar搜索关键词“CAMKK1 antibody”、“CAMKK1 function”等获取最新研究。
The calcium/calmodulin-dependent protein kinase kinase 1 (CAMKK1) antibody is a key tool for studying the CAMKK1 enzyme, a serine/threonine kinase within the Ca²⁺/calmodulin-dependent protein kinase (CAMK) family. CAMKK1 acts as an upstream regulator of AMP-activated protein kinase (AMPK) and other CAMK members, playing pivotal roles in cellular energy homeostasis, cell growth, autophagy, and stress responses. It is implicated in diverse physiological and pathological processes, including cancer progression, metabolic disorders, and neurodegenerative diseases.
CAMKK1 antibodies are designed to detect and quantify CAMKK1 expression in various biological samples. These antibodies are typically developed using immunogens derived from specific regions of the human CAMKK1 protein and are validated for applications such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry. Researchers rely on these antibodies to investigate CAMKK1's tissue distribution, subcellular localization, and interaction with downstream targets.
High-quality CAMKK1 antibodies exhibit specificity, sensitivity, and minimal cross-reactivity with homologous proteins like CAMKK2. Their utility extends to both basic research and preclinical studies, particularly in exploring CAMKK1's role as a potential therapeutic target. Proper validation using knockout controls or peptide blocking experiments is essential to ensure antibody reliability. Commercial variants may differ in host species (e.g., rabbit, mouse), clonality (monoclonal/polyoclonal), and conjugation tags, allowing flexibility for experimental design.
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