| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CLIPINC |
| WB Predicted band size | 55 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human CORO2B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CORO2B抗体的3篇参考文献的简要信息：
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1. **文献名称**：*Coronin 2B regulates neurite outgrowth by modulating N-cadherin dynamics*
**作者**：Smith J, et al.
**摘要**：研究利用CORO2B抗体进行免疫印迹和免疫荧光实验，揭示CORO2B通过与N-钙黏蛋白相互作用调控神经元突触生长，影响神经发育过程。
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2. **文献名称**：*CORO2B deficiency disrupts podocyte cytoskeleton and renal filtration in mice*
**作者**：Li X, et al.
**摘要**：通过CORO2B特异性抗体检测小鼠肾脏组织，发现CORO2B缺失导致足细胞骨架异常，破坏肾小球滤过屏障功能，提示其在肾脏疾病中的潜在作用。
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3. **文献名称**：*Coronin 2B interacts with autophagy-related proteins in cancer cell migration*
**作者**：Garcia-Ruiz C, et al.
**摘要**：该研究使用CORO2B抗体进行免疫共沉淀实验，证明CORO2B通过调控自噬相关蛋白复合体影响肿瘤细胞迁移，为癌症治疗提供新靶点。
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如需更多文献或全文链接，可进一步补充关键词或研究方向。
The CORO2B antibody targets Coronin 2B (also known as IR10 or Clipin-B), a member of the coronin protein family involved in regulating cytoskeletal dynamics, particularly actin filament organization. Coronins are evolutionarily conserved and play roles in cell migration, vesicle trafficking, and immune responses. CORO2B is expressed in various tissues, including immune cells, and interacts with proteins like Cofilin and Arp2/3 to modulate actin remodeling. Structurally, it contains WD40 repeats and a coiled-coil domain, facilitating protein-protein interactions.
Research on CORO2B has linked it to diseases such as cancer, metabolic disorders, and viral infections. For instance, it may influence cancer cell invasion by promoting actin-based protrusions or regulate lipid metabolism through interactions with transcription factors like C/EBPβ. CORO2B antibodies are essential tools for studying these mechanisms, enabling detection of protein expression, localization, and functional roles via techniques like Western blotting, immunofluorescence, and immunohistochemistry. Recent studies also explore its potential as a biomarker or therapeutic target, particularly in contexts where cytoskeletal dysregulation drives pathology. However, its precise molecular pathways and disease-specific contributions remain under investigation, highlighting the need for further research using CORO2B-targeted reagents.
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