| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | BBF2H7 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于CREB3L2抗体的参考文献及其摘要概括：
1. **"CREB3L2-mediated ER stress response promotes glioblastoma growth"**
*作者：Chen X, et al.*
**摘要**：研究利用CREB3L2抗体验证了其在胶质母细胞瘤组织中的高表达，发现CREB3L2通过调控内质网应激相关基因(如ATF4)促进肿瘤细胞存活和侵袭。
2. **"Antibody-based detection of CREB3L2 in invasive breast carcinomas"**
*作者：Luo R, et al.*
**摘要**：通过免疫组化(使用兔源CREB3L2单克隆抗体)发现，CREB3L2蛋白在三阴性乳腺癌中显著上调，并与患者预后不良相关，提示其作为潜在生物标志物。
3. **"CREB3L2 regulates collagen type I in osteogenesis imperfecta"**
*作者：Keller B, et al.*
**摘要**：研究使用Western blot(抗CREB3L2抗体)证实成骨细胞中CREB3L2缺失导致I型胶原分泌异常，揭示了其在骨发育疾病中的分子机制。
4. **"Prognostic value of CREB3L2 in hepatocellular carcinoma"**
*作者：Wang Y, et al.*
**摘要**：通过免疫荧光(小鼠抗人CREB3L2抗体)发现，肝癌组织中CREB3L2核定位与TGF-β信号激活相关，高表达患者生存期显著缩短。
注：以上文献名为示例性虚构，实际引用需根据具体研究调整。建议通过PubMed/Google Scholar以"CREB3L2 antibody" + "cancer"/"mechanism"等关键词检索真实文献。
The cAMP-responsive element-binding protein 3-like 2 (CREB3L2), also known as BBF2H7 or OASIS, is a transcription factor belonging to the CREB/ATF family. It is primarily localized in the endoplasmic reticulum (ER) and plays a critical role in the unfolded protein response (UPR) pathway. Under ER stress, CREB3L2 is proteolytically cleaved, releasing its N-terminal domain, which translocates to the nucleus to regulate genes involved in protein folding, secretion, and ER stress adaptation. This mechanism links cellular stress signaling to transcriptional regulation.
Antibodies targeting CREB3L2 are essential tools for studying its expression, activation, and subcellular localization. They are widely used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to investigate CREB3L2's role in physiological and pathological contexts. Research has implicated CREB3L2 in cancer progression, particularly in sarcomas and breast cancer, where its dysregulation may influence tumor invasiveness and metastasis. Additionally, CREB3L2 variants are associated with genetic disorders like osteogenesis imperfecta, highlighting its importance in connective tissue homeostasis. These antibodies enable the detection of both full-length and cleaved forms, aiding in the study of its activation dynamics. However, specificity validation (e.g., knockout controls) is crucial due to potential cross-reactivity with related CREB3L family members. Overall, CREB3L2 antibodies are vital for unraveling its multifaceted roles in ER stress response and disease mechanisms.
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