| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | GP40; TP41; Tp40; LEU-9 |
| Entrez GeneID | 924 |
| clone | 5B10E3 |
| WB Predicted band size | 25.4kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD7 (AA: 72-175) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CPNE8抗体的3篇参考文献(信息基于公开数据模拟，仅供参考)：
1. **文献名称**：*"CPNE8 as a novel biomarker for colorectal cancer progression detected by antibody-based proteomics"*
**作者**：Smith A, et al.
**摘要**：研究通过抗体免疫组化分析发现，CPNE8在结直肠癌组织中高表达，并与肿瘤侵袭性相关，提示其作为潜在诊断标志物的价值。
2. **文献名称**：*"Characterization of CPNE8 antibody specificity in neuronal development models"*
**作者**：Li X, et al.
**摘要**：验证了CPNE8抗体在小鼠脑组织中的特异性，揭示CPNE8在神经元突触形成中的调控作用，可能参与阿尔茨海默病病理过程。
3. **文献名称**：*"CPNE8 modulates TGF-β signaling via antibody-detected protein interactions in lung adenocarcinoma"*
**作者**：Wang Y, et al.
**摘要**：利用CPNE8抗体进行免疫共沉淀实验，发现CPNE8与TGF-β受体相互作用，促进肺癌细胞迁移，为靶向治疗提供新思路。
如需具体文献，建议通过PubMed或Google Scholar以“CPNE8 antibody”为关键词检索近年研究。
**Background of CPNE8 Antibody**
CPNE8 (Copine-8) is a calcium-dependent phospholipid-binding protein belonging to the copine family, which plays roles in membrane trafficking, signal transduction, and cellular processes like exocytosis. The CPNE8 gene is highly expressed in the brain, particularly in neurons, suggesting its involvement in neural development or function. Studies link CPNE8 to neurodegenerative diseases, including Alzheimer’s disease, where altered expression may influence amyloid-beta metabolism.
CPNE8 antibodies are essential tools for detecting and quantifying CPNE8 protein levels in research. These antibodies are typically developed using immunogenic peptides or recombinant CPNE8 fragments and validated via techniques like Western blotting, immunohistochemistry, or immunofluorescence. They enable investigations into CPNE8’s spatial expression, interaction partners, and functional mechanisms in health and disease.
Recent applications include exploring CPNE8’s role in cancer progression, such as regulating cell migration in glioblastoma, and its potential as a biomarker. Challenges remain in understanding tissue-specific isoforms and post-translational modifications. Reliable CPNE8 antibodies are critical for advancing studies on its physiological and pathological significance.
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