| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ACHAP; C6orf82 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human CUTA |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CUTA抗体的参考文献示例(注：以下文献为虚构示例，实际文献请通过学术数据库验证)：
1. **文献名称**：CUTA Antibody Reveals Its Role in Copper Homeostasis and Alzheimer’s Disease Pathology
**作者**：Kim S, et al. (2012)
**摘要**：研究通过CUTA抗体检测，发现CUTA蛋白与铜转运蛋白ATP7A相互作用，调控神经元内铜稳态失衡，可能参与阿尔茨海默病中β-淀粉样蛋白沉积的病理过程。
2. **文献名称**：Characterization of CUTA Isoforms Using Polyclonal Antibodies in Mammalian Cells
**作者**：Zhao L, et al. (2013)
**摘要**：利用多克隆CUTA抗体鉴定不同物种中CUTA蛋白的亚型，发现其在不同组织中的表达差异，提示其在铜代谢中的组织特异性功能。
3. **文献名称**：CUTA Antibody-Based Detection of Copper Dysregulation in Neurodegenerative Models
**作者**：Brewer GJ, et al. (2015)
**摘要**：综述CUTA抗体在神经退行性疾病模型中的应用，强调CUTA作为铜代谢标志物的潜力，及其在帕金森病和阿尔茨海默病中的诊断价值。
4. **文献名称**：Interaction Between CUTA and APP: Insights from Immunoprecipitation Studies
**作者**：Wang Y, et al. (2017)
**摘要**：通过CUTA抗体进行免疫共沉淀实验，揭示CUTA与淀粉样前体蛋白(APP)的直接结合，可能影响APP加工及铜依赖性氧化应激反应。
**提示**：以上内容为模拟示例，实际研究中请通过PubMed、Google Scholar等平台检索最新文献，并结合具体研究背景筛选。
**Background of CUTA Antibody**
The CUTA antibody targets the CUTA protein, encoded by the *CUTA* gene, which is evolutionarily conserved across eukaryotes. Initially identified in bacteria for its role in divalent cation tolerance, mammalian CUTA is implicated in diverse cellular processes, including acetylcholinesterase (AChE) regulation, metal ion homeostasis, and mitochondrial function. Studies link CUTA to Alzheimer’s disease (AD) pathogenesis, as it interacts with the amyloid precursor protein (APP) and AChE, both critical in synaptic function and AD pathology. CUTA exists in multiple isoforms, with differential subcellular localization (e.g., cytoplasm, mitochondria, endoplasmic reticulum), suggesting varied functional roles.
CUTA antibodies are essential tools for investigating its expression, localization, and interactions in disease models. They enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Research utilizing CUTA antibodies has revealed its dysregulation in neurodegenerative disorders, cancers, and metal toxicity, highlighting its potential as a therapeutic or diagnostic target. Despite progress, the precise molecular mechanisms of CUTA remain partially understood, necessitating further studies to elucidate its pathophysiological significance.
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