| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | RHFCA; CYP26A2; P450RAI2; P450RAI-2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human CYP26B1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是与CYP26B1抗体相关的3篇文献摘要整理：
1. **《CYP26B1 regulates retinoic acid-mediated germ cell development in mice》**
- 作者：MacLean, G. et al.
- 摘要：研究利用CYP26B1特异性抗体，通过免疫组化揭示该酶在小鼠睾丸组织中的定位，证明其通过降解维甲酸调控生殖细胞分化，缺失导致精子发生异常。
2. **《Dysregulated CYP26B1 expression in human cancers》**
- 作者：Tahayato, A. et al.
- 摘要：通过Western blot和免疫荧光分析多种癌症样本，发现CYP26B1在乳腺癌和肺癌中高表达，提示其可能通过干扰维甲酸信号通路促进肿瘤进展。
3. **《CYP26B1 modulates neurogenesis through retinoic acid clearance in the developing brain》**
- 作者：Sakai, Y. et al.
- 摘要：使用CYP26B1抗体进行脑组织染色，发现其在胚胎小鼠神经前体细胞中表达，抑制维甲酸过度积累，维持皮层神经发生的正常时序。
注：实际文献需通过PubMed/Google Scholar检索确认，上述为基于领域知识的模拟示例。建议结合具体研究需求补充实验方法学验证抗体验证信息(如宿主物种、应用场景等)。
CYP26B1 antibody is a research tool targeting the cytochrome P450 family 26 subfamily B member 1. an enzyme critical in regulating retinoic acid (RA) homeostasis. RA, a vitamin A derivative, acts as a signaling molecule in cellular differentiation, proliferation, and embryonic development. CYP26B1 specifically metabolizes RA into inactive forms, controlling its spatial and temporal distribution in tissues. This enzyme is expressed in various organs, including the brain, skin, and reproductive tissues, where precise RA gradients are essential for normal function. Dysregulation of CYP26B1 has been linked to developmental disorders, skin pathologies, and cancer progression.
The CYP26B1 antibody enables detection and quantification of the enzyme in experimental models, facilitating studies on RA signaling dynamics. It is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate CYP26B1 expression patterns in health and disease. Researchers employ this antibody to explore mechanisms underlying neural development, bone homeostasis, and epidermal differentiation, as well as to assess therapeutic targets in RA-dependent malignancies. Validation of antibody specificity through knockout controls or siRNA knockdown is crucial, given the structural similarities among CYP26 family members. Recent studies also utilize this tool to examine CYP26B1's role in immune modulation and its potential as a biomarker in clinical contexts.
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