| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | LIC1; DLC-A; DNCLI1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human DYNC1LI1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DYNC1LI1抗体的3篇参考文献及其摘要内容：
1. **文献名称**: "DYNC1LI1 regulates cargo-specific retrograde transport in neurons"
**作者**: Smith A, et al.
**摘要**: 本研究利用DYNC1LI1特异性抗体，通过免疫荧光和共聚焦显微镜技术，揭示了DYNC1LI1在神经元轴突运输中对特定囊泡逆行运输的调控作用，并证明其缺失导致神经递质运输障碍。
2. **文献名称**: "Role of DYNC1LI1 in mitotic spindle organization"
**作者**: Chen L, et al.
**摘要**: 通过DYNC1LI1抗体进行Western blot和免疫沉淀实验，作者发现DYNC1LI1与有丝分裂纺锤体组装相关，其功能异常会导致染色体分离错误和细胞周期停滞。
3. **文献名称**: "DYNC1LI1 interacts with viral capsid proteins during infection"
**作者**: Gomez-Ramos P, et al.
**摘要**: 该研究使用DYNC1LI1抗体验证了宿主细胞动力蛋白复合体与多种病毒衣壳蛋白的相互作用，表明DYNC1LI1在病毒胞内运输和感染过程中起关键作用。
注：以上文献信息为模拟示例，实际引用需根据具体研究查询真实数据库(如PubMed)。
The DYNC1LI1 antibody is a research tool designed to detect and study the cytoplasmic dynein 1 light intermediate chain 1 (DYNC1LI1), a critical subunit of the dynein motor protein complex. Dynein is a microtubule-associated motor protein involved in intracellular transport, organelle positioning, mitosis, and cell migration. DYNC1LI1. encoded by the *DYNC1LI1* gene, functions as part of the dynein-dynactin complex, facilitating cargo binding and regulating dynein’s motor activity.
Researchers use DYNC1LI1 antibodies in applications like Western blotting, immunofluorescence, and immunoprecipitation to investigate DYNC1LI1 expression, localization, and interactions. These studies are vital for understanding cellular processes such as neuronal transport, ciliary function, and cell division. Dysregulation of dynein complexes, including DYNC1LI1. has been linked to neurodevelopmental disorders, neurodegenerative diseases (e.g., ALS), and ciliopathies. The antibody’s specificity and reliability make it valuable for exploring dynein’s role in health and disease. Validated in various models (e.g., mammalian cells, tissues), DYNC1LI1 antibodies help uncover mechanisms underlying intracellular trafficking defects and potential therapeutic targets.
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