| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | LG72; SG72 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DAOA(D-amino acid oxidase activator)抗体的模拟参考文献示例(非真实文献，仅供格式参考)：
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1. **文献名称**: *DAOA Protein Expression in Schizophrenia: A Post-Mortem Brain Study*
**作者**: Smith J, et al.
**摘要**: 该研究使用特异性DAOA抗体对精神分裂症患者脑组织进行免疫组化分析，发现前额叶皮层中DAOA蛋白表达显著降低，提示其与疾病病理机制相关。
2. **文献名称**: *Autoantibodies Against DAOA in Neuropsychiatric Disorders*
**作者**: Tanaka K, et al.
**摘要**: 首次报道在部分躁郁症患者血清中检测到DAOA自身抗体，并通过体外实验证明这些抗体可能干扰DAOA的酶激活功能，导致神经递质代谢异常。
3. **文献名称**: *DAOA Antibody-Based Detection in Glutamate Signaling Pathways*
**作者**: Müller R, et al.
**摘要**: 利用DAOA单克隆抗体进行蛋白质相互作用研究，揭示了DAOA通过调节D-氨基酸氧化酶活性影响谷氨酸能突触传递的分子机制。
4. **文献名称**: *DAOA as a Novel Biomarker in Autoimmune Encephalitis*
**作者**: Lee S, et al.
**摘要**: 通过ELISA和蛋白质印迹技术，发现自身免疫性脑炎患者脑脊液中存在DAOA抗体，提示其可能作为诊断标志物或治疗靶点。
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**注意**：以上文献为模拟示例，实际研究中需通过学术数据库(如PubMed、Web of Science)检索真实文献。若需具体文章，可提供关键词进一步协助筛选。
The DAOA (D-amino acid oxidase activator) gene, also known as G72. encodes a protein implicated in modulating D-amino acid oxidase (DAAO) activity, which regulates D-serine metabolism—a co-agonist of NMDA receptors critical for glutamatergic neurotransmission. First identified in the early 2000s through genetic linkage studies, DAOA gained attention for its potential association with psychiatric disorders, particularly schizophrenia and bipolar disorder. Variations in the DAOA gene have been linked to altered NMDA receptor function, contributing to the "glutamate hypothesis" of schizophrenia, which posits dysregulated glutamatergic signaling as a key pathogenic mechanism.
DAOA antibodies, specifically targeting the encoded protein, emerged as tools to study its expression, localization, and interaction with DAAO in neural tissues. Research suggests DAOA may act as a chaperone or stabilizer for DAAO, influencing D-serine levels and NMDA receptor activity. However, findings remain controversial, with inconsistent replication of its genetic association with psychiatric diseases. DAOA antibodies are also explored for diagnostic or therapeutic applications, though clinical utility is unproven. Current studies focus on clarifying DAOA's physiological role, its interaction with synaptic proteins, and potential as a biomarker or drug target in neuropsychiatric conditions. Challenges include understanding tissue-specific expression and resolving discrepancies between genetic and functional data.
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