| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | SGD; DAGD; 35DAG; CMD1L; SGCDP; SG-delta |
| WB Predicted band size | 32 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human SGCD |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SGCD抗体的参考文献示例(注：内容为虚构，仅作格式参考)：
1. **文献名称**：*Delta-sarcoglycan (SGCD) antibody validation in muscular dystrophy models*
**作者**：Smith A, et al.
**摘要**：研究验证了SGCD抗体在多种肌营养不良动物模型中的特异性，通过免疫组化和Western blot证实其在检测SGCD蛋白缺失中的可靠性，为疾病诊断提供工具。
2. **文献名称**：*SGCD autoantibodies in idiopathic cardiomyopathy: a biomarker study*
**作者**：Chen L, et al.
**摘要**：探讨了特发性心肌病患者血清中SGCD自身抗体的存在及其临床意义，发现其与心室功能恶化相关，提示免疫机制可能参与疾病进展。
3. **文献名称**：*Comparative analysis of SGCD antibody performance in immunohistochemistry*
**作者**：Rodriguez M, et al.
**摘要**：系统比较了市售SGCD抗体的敏感性和特异性，提出优化实验条件以提高在人类骨骼肌和心肌组织中的染色一致性。
4. **文献名称**：*SGCD deficiency and antibody-based therapeutic strategies in limb-girdle dystrophy*
**作者**：Tanaka K, et al.
**摘要**：研究利用SGCD抗体评估肢带型肌营养不良症患者的蛋白表达水平，并探索基于抗体靶向的基因治疗监测方法。
(注：以上文献为示例，实际引用请通过PubMed或Google Scholar检索真实研究。)
The sarcoglycan complex, part of the dystrophin-glycoprotein complex (DGC), plays a critical role in stabilizing muscle cell membranes during contraction. SGCD (δ-sarcoglycan) is a transmembrane protein encoded by the SGCD gene, predominantly expressed in skeletal and cardiac muscle. Mutations in SGCD are linked to limb-girdle muscular dystrophy type 2F (LGMD2F) and dilated cardiomyopathy, highlighting its importance in maintaining structural integrity and signaling in muscle tissues.
SGCD antibodies are autoantibodies targeting the δ-sarcoglycan protein. While rare, their presence is associated with autoimmune myopathies, particularly in overlap syndromes involving cardiac or skeletal muscle inflammation. These antibodies may disrupt the sarcoglycan complex, leading to membrane fragility, impaired force transmission, and muscle degeneration. Detection of SGCD antibodies (via immunoprecipitation or immunoassay) aids in diagnosing autoimmune-mediated muscle disorders, though they are less common than other myositis-specific autoantibodies.
Research on SGCD antibodies remains limited, but their identification contributes to understanding autoimmune mechanisms in neuromuscular diseases. Clinical relevance includes potential correlations with disease severity or cardiac involvement, warranting further investigation to refine diagnostic and therapeutic strategies.
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