| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | OFD5; ZNHIT5 |
| WB Predicted band size | 69 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human DDX59 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DDX59抗体的模拟参考文献示例(非真实文献，仅供格式参考)：
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1. **文献名称**: *DDX5**9 Antibody Validation in Ciliopathy Models*
**作者**: Smith A, et al.
**摘要**: 本研究通过Western blot和免疫荧光技术验证了DDX59抗体的特异性，发现DDX59在纤毛相关疾病模型(如Joubert综合征)中表达异常，提示其可能参与纤毛RNA代谢调控。
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2. **文献名称**: *DDX59 as a Novel Biomarker in Esophageal Squamous Cell Carcinoma*
**作者**: Li X, et al.
**摘要**: 利用DDX59抗体进行免疫组化分析，发现其在食管鳞癌组织中高表达，且与患者预后不良相关，表明DDX59可能作为癌症治疗的潜在靶点。
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3. **文献名称**: *Functional Characterization of DDX59 in Ribosome Biogenesis*
**作者**: Garcia-Ruiz C, et al.
**摘要**: 通过DDX59抗体的免疫沉淀实验，揭示了DDX59在核糖体RNA前体加工中的关键作用，并证实其突变可导致发育障碍综合征。
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4. **文献名称**: *DDX59 Antibody Cross-Reactivity Analysis in DEAD-Box Proteins*
**作者**: Tanaka K, et al.
**摘要**: 系统评估了DDX59抗体与其他DEAD-box家族蛋白的交叉反应性，确认其在人源细胞系中的高特异性，为相关功能研究提供可靠工具。
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**注意**：以上内容为模拟示例，实际文献需通过PubMed、Google Scholar等平台检索。建议使用关键词“DDX59 antibody”、“DDX59 AND (function/disease)”查找最新研究。
The DDX59 antibody is a research tool designed to detect and study the DDX59 protein, a member of the DEAD-box helicase family involved in RNA metabolism. DDX59. encoded by the DDX59 gene, plays roles in RNA processing, ribosome biogenesis, and ciliogenesis. It contains conserved DEAD-box motifs that enable ATP-dependent RNA unwinding, critical for cellular functions like transcriptional regulation and cell cycle progression. Mutations in DDX59 are linked to orofaciodigital syndrome type V (OFD5), a rare genetic disorder characterized by craniofacial abnormalities, polydactyly, and ciliary dysfunction, highlighting its importance in developmental processes.
DDX59 antibodies are primarily used in experimental settings—such as Western blotting, immunofluorescence, and immunohistochemistry—to investigate protein expression, localization, and interactions. These antibodies help researchers explore DDX59's role in cilia formation, its involvement in signaling pathways (e.g., Hedgehog), and its dysregulation in diseases. Commercially available DDX59 antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes to ensure specificity. Validated antibodies are crucial for distinguishing DDX59 from related DEAD-box proteins and for advancing studies on ciliopathies and developmental disorders. Ongoing research aims to clarify its mechanistic contributions to disease and potential therapeutic targets.
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