| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | BAT1; DDXL; BAT1L; DDX39; URH49 |
| WB Predicted band size | 49 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human DDX39A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是3-4条关于 **DDX39A抗体** 的参考文献示例(注：以下为模拟虚构内容，实际文献请通过学术数据库查询)：
---
1. **文献名称**: *DDX39A interacts with the splicing machinery and promotes RNA splicing in human cells*
**作者**: Smith A, et al.
**摘要**: 本研究利用DDX39A特异性抗体进行免疫共沉淀(Co-IP)和免疫荧光实验，发现DDX39A与剪接体复合物相互作用，并通过调控前体mRNA剪接影响基因表达。
---
2. **文献名称**: *DDX39A expression correlates with cancer progression and immune infiltration*
**作者**: Zhang Y, et al.
**摘要**: 通过免疫组化(IHC)结合DDX39A抗体分析肿瘤组织样本，发现DDX39A在多种癌症中高表达，其水平与患者预后不良及肿瘤微环境中的免疫细胞浸润相关。
---
3. **文献名称**: *DDX39A is essential for viral RNA unwinding and innate immune signaling*
**作者**: Lee H, et al.
**摘要**: 使用DDX39A敲除细胞系及特异性抗体验证，发现DDX39A通过解旋病毒RNA促进RIG-I信号通路激活，在抗病毒天然免疫应答中发挥关键作用。
---
4. **文献名称**: *Structural insights into the ATP-dependent RNA helicase activity of DDX39A*
**作者**: Tanaka K, et al.
**摘要**: 通过抗体制备和冷冻电镜技术解析DDX39A蛋白结构，揭示了其依赖ATP的RNA解旋酶活性机制，为靶向DDX39A的药物设计提供依据。
---
如需真实文献，建议在 **PubMed** 或 **Google Scholar** 中检索关键词 "DDX39A antibody" 或结合具体研究场景筛选。
DDX39A (also known as UAP56 or BAT1) is a member of the DEAD-box RNA helicase family, which plays critical roles in RNA metabolism, including pre-mRNA splicing, nuclear export, and translation. This ATP-dependent enzyme facilitates the unwinding of RNA secondary structures and participates in spliceosome assembly by recruiting key components to nascent transcripts. Dysregulation of DDX39A has been implicated in cancer, neurodegenerative diseases, and viral infections, highlighting its importance in cellular homeostasis.
Antibodies targeting DDX39A are essential tools for studying its expression, localization, and molecular interactions. They are widely used in techniques such as Western blotting, immunofluorescence, and immunoprecipitation to investigate DDX39A's role in RNA processing and disease mechanisms. For instance, researchers employ these antibodies to analyze DDX39A overexpression in malignancies or its reduced activity in aging-related neurological disorders. Validated antibodies often undergo specificity checks using knockout cell lines or siRNA knockdown to ensure minimal cross-reactivity with homologous proteins like DDX39B. Commercial antibodies typically cite applications in detecting the ~50 kDa protein across human, mouse, and rat samples. Ongoing research also explores DDX39A's potential as a therapeutic target or biomarker, driving demand for reliable antibody reagents. Suppliers such as Abcam, Cell Signaling Technology, and Santa Cruz Biotechnology provide DDX39A antibodies, though performance may vary depending on epitope regions and experimental conditions.
×
